Votre recherche pour: ENZO LIFE SCIENCES

Fournisseur: ENZO LIFE SCIENCES

Description: The IHC PAP pen provides a hydrophobic barrier when a circle is drawn around a specimen on a glass slide.

Référence Produit: (ENZOADI960074)

Fournisseur: ENZO LIFE SCIENCES

Description: For the quantitative determination of αB-Crystallin in cell lysates of human, mouse, rat, and cow origin.

UOM: 1 * 1 SET

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Référence Produit: (ENZOADI9501000001)

Fournisseur: ENZO LIFE SCIENCES

Description: Mouse-HRP/rabbit-AP IHC is a biotin-free one-step detection system suitable for demonstrating antigens in formalin-fixed paraffin-embedded tissues and cryostat sections.

UOM: 1 * 100 Tests

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Référence Produit: (ENZOADI9501130100)

Fournisseur: ENZO LIFE SCIENCES

Description: Immunohistochemistry (mouse/rabbit-HRP) detection reagent is a non-biotin one-step detection reagent.

UOM: 1 * 100 Tests

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Référence Produit: (ENZOADI9501510030)

Fournisseur: ENZO LIFE SCIENCES

Description: Blue IHC chromogen (HRP) is intended to be used in conjunction with horseradish peroxidase (HRP)-based immunostaining or <i>in situ</i> hybridisation systems.

UOM: 1 * 30 mL

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Référence Produit: (ENZOADIAAM080E)

Fournisseur: ENZO LIFE SCIENCES

Description: The Bcl-2 family of proteins regulate the intrinsic apoptotic pathway and are characterized by the sharing of at least one of four conserved Bcl-2 Homology (BH) domains.

UOM: 1 * 100 µG

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Fournisseur: ENZO LIFE SCIENCES

Description: The human Cullin family of genes consists of Cul-1, Cul-2, Cul-3, Cul-4a, Cul-4b, and Cul-5. Among the 6 members, Cul-1 and Cul-2 are very well characterized. Cul-2 is homologous to the Saccharomyces cerevisiae cdc53 gene. Studies have shown that Cul-1 forms an E3 ubiquitin-ligase, called the SCF complex (Skp1 and F-box protein such as bTrCp or FWD1), which controls the proteolysis of G1 cell cycle regulatory proteins.

Référence Produit: (ENZOADIKAPGP126D)

Fournisseur: ENZO LIFE SCIENCES

Description: The Ras superfamily of small guanosine triphosphatases (GTPases) is traditionally subdivided into five families: Ras, Rho, Rab, Ran, and Arf. Rap1/Krev1 is a member of the Ras family of low molecular weight GTP-binding proteins1. Ras-like GTPases are ubiquitously expressed, evolutionarily conserved molecular switches that couple extracellular signals to various cellular responses. Rap1 is primarily found at the cytosolic side of intracellular membranes and has two isoforms: Rap1a and 1b2. Both isoforms have a molecular mass of 21 kDa and are isoprenylated at the carboxyl-terminal and phosphorylated by the cAMP-dependent protein kinase A (PKA)3. Rap1 cycles between a GTP-bound active form and a GDP-bound inactive form that is mediated by GTPase activating protein (GAP) and GDP dissociation stimulator (GDS)4,5. Activation occurs by a variety of extracellular stimuli through several conserved guanine nucleotide exchange factors (GEFs) and GTPase activating proteins (GAPs). Rap1 is proposed to regulate Ras mediated signaling and may also be involved in the regulation of integrinmediated cell adhesion, although the mechanism of regulation is not known. Overexpression of Rap reverses the transformed phenotype induced by Ras, possibly by competing with Ras for interaction with Ras-GAP. Rap has been shown to participate in MAP kinase cascade activated by growth factor and maintaining human T cell anergic state by blocking IL-2 expression.

UOM: 1 * 50 µG

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Référence Produit: (ENZOADIKAPST010E)

Fournisseur: ENZO LIFE SCIENCES

Description: The casein kinases are serine/threonine protein kinases involved in the regulation of multiple cell signaling pathways. There are at least seven identified mammalian isoforms in the casein kinase I (CKI) family, which are monomeric and function in cell growth and the replication and repair of DNA. Casein kinase II (CK2) is a ubiquitous tetrameric holoenzyme comprised of two catalytic alpha subunits and two regulatory beta subunits. CK2 enzymes are known to regulate metabolic signal transduction, transcription, and translation.

UOM: 1 * 100 µG

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Référence Produit: (ENZOADIKAMCC200E)

Fournisseur: ENZO LIFE SCIENCES

Description: Cyclins are a family of proteins which function as the regulatory subunits of cyclin/cyclin-dependent kinase (Cdk) holoenzymes, mediating entry into and progression through the cell cycle. Each cyclin is expressed in a temporal fashion during the cell cycle, partnering with a specific Cdk to activate its protein kinase activity. The most well defined mitotic cyclins are: cyclin D, which partners with cdks 4 and 6 during early G1 phase; cyclin E, which activates Cdk2 in the G1 to S phase transition; cyclin A, which utilizes Cdks 1 and 2 during progression through S phase and into G2; and cyclin B, which activates Cdk1 in M-phase promotion.

UOM: 1 * 100 µG

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Fournisseur: ENZO LIFE SCIENCES

Description: Glycogen Synthase Kinase 3β (GSK-3β) is a unique serine/threonine kinase that is inactivated by phosphorylation. In response to insulin binding, PKB/AKT phosphorylates GSK-3β on serine 9, which prevents GSK-3β from phosphorylating glycogen synthase. Unphosphorylated glycogen synthase is active and able to synthesize glycogen. GSK-3β is also unique in that it requires a substrate that has been phosphorylated by a distinct kinase before it can phosphorylate the substrate. This phosphate priming mechanism explains why phosphorylation of serine 9 inactivates GSK-3β. The phosphorylated serine binds to the GSK-3β priming phosphate position and prevents binding of alternative substrates. In addition to insulin signaling, GSK-3β participates in the Wnt signaling pathway, where it forms a complex with axin, beta-catenin and adenomatous polyposis coli (APC) protein. In the presence of Wnts, GSK-3β is unable to phosphorylate beta-catenin, which leads to stabilization of beta-catenin. The Wnt pathway inactivates GSK-3β via the proteins, Dishevelled and FRAT, which disrupt the interaction of GSK-3β with axin, beta-catenin, and APC. Clinically, there is considerable interest in GSK-3β inhibitors because they may mimic the effect of insulin or reduce the hyperphosphorylation of Tau that is observed in Alzheimer's Disease.

Référence Produit: (ENZOADIKAMCC250E)

Fournisseur: ENZO LIFE SCIENCES

Description: Vimentin is one of four type II intermediate filament (IF) proteins; Desmin, Glial fibrillary acidic protein (GFAP) and Peripherin being the others. Vimentin is the most widely distributed of all IF proteins. It is typically expressed in leukocytes, blood vessel endothelial cells, and mesenchymal cells such as fibroblasts. Vimentin filaments help support cellular membranes. Vimentin networks also may help keep the nucleus and other organelles in a defined place within the cell.

UOM: 1 * 100 µG

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Référence Produit: (ENZOADIEKS700B)

Fournisseur: ENZO LIFE SCIENCES

Description: Widely used ELISA HSP70 kit for chaperone and stress research.

UOM: 1 * 1 KIT

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Référence Produit: (ENZOADIEKS500)

Fournisseur: ENZO LIFE SCIENCES

Description: Most comprehensive portfolio of heat shock protein (chaperone) products commercially available.

UOM: 1 * 1 KIT

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Référence Produit: (ENZOADINBA100E)

Fournisseur: ENZO LIFE SCIENCES

Description: APP695 is the most predominant form in neuronal tissue while APP751 is the predominant form found elsewhere. There are five forms of APP: APP395, APP563, APP695, APP751, and APP770.

UOM: 1 * 100 µG

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Fournisseur: ENZO LIFE SCIENCES

Description: The diffusible free radical gas nitric oxide (NO) affects a variety of physiological functions, and is a key regulator of the cardiovascular, nervous, and immune systems. NO is synthesized in many tissues from L-arginine, oxygen, and NADPH by three known isoforms of a heme-containing flavoprotein termed NO synthase (nNOS/NOS-I, iNOS/NOS-II, and eNOS/NOS-III). nNOS is a constitutively expressed neuronal NOS isoform that exits in its latent form until it is activated by the binding of calmodulin follo wing elevation of intracellular calcium levels. The C-terminus of nNOS contains a conserved serine residue, Ser1417, analogous to Ser1177 of the constitutively expressed endothelial NOS isoform (eNOS). Phosphorylation of Ser1417 is believed to regulate nNOS activation, particularly in glucose-sensing neurons, where inhibition of AMPK pathways by glucose and leptin serve to suppress nNOS activity, whereas activation of AMPK by insulin leads to nNOS activation.