Votre recherche pour: ENZO LIFE SCIENCES

Référence Produit: (ENZOADI908066010)

Fournisseur: ENZO LIFE SCIENCES

Description: Produced in <i>E.coli</i>.

UOM: 1 * 10 µG

*Promo

Fournisseur: ENZO LIFE SCIENCES

Description: Chemiluminescent acridinium esters are commonly used to label antibodies, proteins, nucleic acids, and some peptides, and are frequently used as detection reagents in immunoassays.

Référence Produit: (ENZOADI905780100)

Fournisseur: ENZO LIFE SCIENCES

Description: The nucleosome is made up of four core histone proteins (H2A, H2B, H3 and H4) and is the primary building block of chromatin. The core histones form an octamer, which is made up of one H3-H4 tetramer and two H2A-H2B dimers. The N-terminal tail of core histones undergoes different post-transcriptional modifications including acetylation, phosphorylation, methylation and ubiquitination. These modifications occur in response to cell signal stimuli and have a direct effect on gene expression.

UOM: 1 * 100 µG

*Promo

Référence Produit: (ENZOADI905747100)

Fournisseur: ENZO LIFE SCIENCES

Description: Bradykinin (BK) is a nine-amino acid peptide produced by kallikrein cleavage of kininogen precursor proteins in tissue and plasma, and is an important regulator of vascular and pain responses to tissue injury. Two receptors (B1 and B2) have been identified as mediators of BK signaling, and are both seven-transmembrane domain-containing GPCRs. The B2 receptor is constitutively expressed in smooth muscle and neurons, whereas B1 expression is induced following injury. B2 receptors signal via Gq alpha subunits, leading to activation of phospholipase Cbeta, hydrolysis of PI, and an intracellular increase in free calcium, although coupling through Gi, Gs, and G12/13 has also been observed.

UOM: 1 * 100 µG

*Promo

Référence Produit: (ENZOADI905789100)

Fournisseur: ENZO LIFE SCIENCES

Description: Dopamine is the predominant catecholamine neurotransmitter in the mammalian brain, where it regulates locomotor, emotional, memory, and dietary intake functions, as well as peripheral roles such as hormone secretion and renal function. Dopamine receptors (D1-D5) are members of the seven transmembrane domain containing G-protein coupled receptor (GPCR) family A, and are the target of several anti-psychosis and anti-Parkinsonian drugs. The D2, D3, and D4 dopamine receptors are encoded by homologous intron-containing genes, and signal via coupling of Gi/Go alpha G-protein subunits to inhibit adenylyl cyclase activity, as well as modulate cellular ion channel conductance of K+ and Ca2+. This is in contrast to D1 and D5 dopamine receptors, which signal via Gs alpha subunits to activate adenylyl cyclase activity. Coactivation of D1 and D2 receptors has been shown to activate a Gq mediated pathway, stimulating phospholipase C (PLC) and mobilizing intracellular calcium stores. D1 receptors were initially characterized in the striatum and retina and are expressed throughout the brain in the olfactory tubercle, islands of Calleja, entopeduncular nucleus, neocortex, hippocampus, and amygdala. Expression of the D2 receptor is found primarily in the brain (striatum, olfactory tubercle, and nucleus accumbens) and in the anterior and intermediate lobes of the pituitary.

UOM: 1 * 100 µG

*Promo

Référence Produit: (ENZOADI905759100)

Fournisseur: ENZO LIFE SCIENCES

Description: Glycogen Synthase Kinase 3 (GSK3) exists in two isoforms, alpha and beta (GSK3α, and GSK3β). GSK3 is an active kinase that becomes phosphorylated by PKB/akt upon growth factor stimulation. Phosphorylation of GSK3α at serine 21 or GSK3β at serine 9, respectively, leads to inhibition of kinase activity of the GSK3.

UOM: 1 * 100 µG

*Promo

Référence Produit: (ENZOADI905740100)

Fournisseur: ENZO LIFE SCIENCES

Description: Dopamine is the predominant catecholamine neurotransmitter in the mammalian brain, where it regulates locomotor, emotional, memory, and dietary intake functions, as well as peripheral roles such as hormone secretion and renal function. Dopamine receptors (D1-D5) are members of the seven transmembrane domain containing GPCR family, and are the target of several anti-psychosis and anti-Parkinsonian drugs. The D2, D3, and D4 receptors signal via coupling of Gi/Go alpha G-protein subunits to inhibit adenylyl cyclase activity and modulate cellular potassium and calcium ion channel conductance. Expression of the D2 receptor is found primarily in the brain (striatum, olfactory tubercle, and nucleus accumbens) and in the anterior and intermediate lobes of the pituitary.

UOM: 1 * 100 µG

*Promo

Référence Produit: (ENZOADI905787100)

Fournisseur: ENZO LIFE SCIENCES

Description: Bradykinin (BK) is a nine-amino acid peptide produced by kallikrein cleavage of kininogen precursor proteins in tissue and plasma, and is an important regulator of vascular and pain responses to tissue injury. Two receptors (B1 and B2) have been identified as mediators of BK signaling, and are both members of the seven-transmembrane domain-containing G-protein coupled receptor (GPCR) family. The B2 receptor is constitutively expressed in smooth muscle and neurons, whereas B1 expression is induced following tissue injury or during inflammation. The B2 receptor displays high affinity for BK and Lys-BK peptide agonists, while the B1 receptor displays highest affinity to des-Arg9-BK and des-Arg10-kallidin. Both receptors are best characterized as signaling via coupling to Gq alpha subunits (particularly Gq/11), leading to activation of phospholipase C beta, hydrolysis of PI, and an intracellular increase in free calcium, although coupling through Gi, Gs, and G12/13 has also been observed.

UOM: 1 * 100 µG

*Promo

Référence Produit: (ENZOADI905781100)

Fournisseur: ENZO LIFE SCIENCES

Description: Septin 5 (Sept5/CDCrel-1) is a member of the Septin family of cytoskeletal GTPases. Septin 5 expression is primarily associated with synaptic vesicles in cells of the nervous system where it acts to inhibit exocytosis, although it has also been characterized as an inhibitor of aggregation and release of storage granules in platelets. Phosphorylation of Septin 5 at Ser17 by Cdk5-p35 has been shown to mediate the interaction of Septin 5 with the SNARE protein Syntaxin-1A, regulating neurotransmitter release. Targeted disruption of the Septin 5 gene in mice failed to produce an obvious neurological phenotype, indicating its loss may be overcome by functional redundancy of other septins. Septin 5 is one of several Parkin (an E3 ubiquitin ligase) associated substrates whose accumulation results in cellular toxicity related to the onset of autosomal recessive Parkinson Disease.

UOM: 1 * 100 µG

*Promo

Référence Produit: (ENZOADI901093)

Fournisseur: ENZO LIFE SCIENCES

Description: For the quantitative determination of DHEA in culture supernatants, plasma, serum, saliva, and urine from any species.

UOM: 1 * 1 KIT

*Promo

Référence Produit: (ENZOADI905016100)

Fournisseur: ENZO LIFE SCIENCES

Description: Prostaglandin F2alpha (PGF2alpha) is formed in a variety of cells from PGH2, which itself is synthesized from arachidonic acid by the enzyme prostaglandin synthetase. PGF2alpha is often viewed as an antagonist to PGE2 due to their opposing effects on various tissues. PGF2alpha is a potent bronchoconstrictor and has been implicated in asthma attacks. PGF2alpha is also involved in reproductive functions including corpus luteum regulation, uterine contractions, and sperm motility. This has led to its use in terminating pregnancies and inducing labor at term. High levels of PGF2alpha have also been associated with preeclampsia.

UOM: 1 * 100 µl

*Promo

Référence Produit: (ENZOADI901068)

Fournisseur: ENZO LIFE SCIENCES

Description: For the quantitative determination of LTB4 in culture supernatants, plasma, saliva, and urine from any species. Cited sample types include bronchioalveolar lavage fluid, cell lysate, crevicular fluid, tissue, serum and whole blood.

UOM: 1 * 1 KIT

*Promo

Référence Produit: (ENZOADI905053100)

Fournisseur: ENZO LIFE SCIENCES

Description: HETEs are byproducts generated by the metabolism of arachidonic acid by lipoxygenases. 12(S)-HETE is the stereospecific hydroxy product from the reduction of 12(S)-hydroperoxy tetraenoic eicosatetraenoic acid [12(S)-HpETE], which itself is a 12-lipoxygenase metabolite of arachidonic acid. 12(S)-HETE is chemotactic and chemokinetic for polymorphonuclear leukocytes and vascular smooth muscle cells. It also acts as a second messenger in angiotensin-II induced aldosterone production. 15-hydroxyeicosatetraenoic acid [15(S)-HETE] is the major hydroxy derivative of arachidonic acid when acted upon by 15-lipoxygenase. It is also the primary monohydroxy acid synthesized by the lipoxygenase activity of Cyclooxygenase-1 upon linoleic acid. 15(S)-HETE acts as a paracrine regulator of smooth muscle and lung neutrophil recruitment, and elevated levels of 15(S)-HETE are associated with asthma, rhinitis, chronic paranasal sinusitis and rheumatoid arthritis.

UOM: 1 * 100 µl

*Promo

Référence Produit: (ENZOADI900165)

Fournisseur: ENZO LIFE SCIENCES

Description: Most comprehensive portfolio of heat shock protein (chaperone) products commercially available.

UOM: 1 * 1 KIT

*Promo

Référence Produit: (ENZOADI900205)

Fournisseur: ENZO LIFE SCIENCES

Description: The LVV Hemorphin 7 ELISA Kit is a colorimetric, competitive immunoassay kit for the quantitative determination of species independent LVV Hemorphin 7 in serum and tissue homogenate samples.

UOM: 1 * 1 KIT

*Promo

Référence Produit: (ENZOADI9002120001)

Fournisseur: ENZO LIFE SCIENCES

Description: Highly validated, quantitative p62 ELISA kit available for autophagy research.

UOM: 1 * 1 KIT

*Promo