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Rp-cAMPS ≥98% (par HPLC)

Référence Produit: (ENZOBMLCN1350001)
Fournisseur: ENZO LIFE SCIENCES
Description: Rp-cAMPS is a potent and specific competitive inhibitor of the activation of cAMP-dependent protein kinases by cAMP (IC50=4.9 µM) . Its cell permeability and complete resistance to cyclic nucleotide phosphodiesterases make it a unique tool for studying cAMP-dependent signaling. Significantly more lipophilc as compared to cAMP and thus membrane permeable in many biological systems. This product is not sterile.
UOM: 1 * 1 mg
Image Unavailable-ENZOBMLST4050005

(±)-Propranolol hydrochloride ≥98% (par HPLC)

Référence Produit: (ENZOBMLST4050005)
Fournisseur: ENZO LIFE SCIENCES
Description: Propranolol blocks PLD derived DAG formation by inhibiting phosphatidate phosphohydrolase (IC50=70 µM). It is a useful tool to discriminate between PLC or PLD mediated DAG production. It is also a β-adrenergic receptor blocking agent.
UOM: 1 * 5 g
Product Image-ENZOBMLCM1100100

Bafilamycin A1 ≥95% (par HPLC, TLC)

Référence Produit: (ENZOBMLCM1100100)
Fournisseur: ENZO LIFE SCIENCES
Description: Macrolide antibiotic that acts as a potent and selective inhibitor of vacuolar-type H<sup>+</sup>-ATPase (V-type) (IC<sub>50</sub>=004 - 0.4 nmol/mg). Valuable tool for distinguishing among different types of ATPases. Inhibitor of endosomal acidification. Blocks lysosomal cholesterol trafficking in macrophages. Blocks pH regulation in brain cells.
UOM: 1 * 100 µG
Image Unavailable-ENZOBMLEI3880010

BML-277 Chk2 inhibitor ≥98% (par CCM)

Référence Produit: (ENZOBMLEI3880010)
Fournisseur: ENZO LIFE SCIENCES
Description: BML-277 is a highly selective inhibitor of Chk2 (IC50=15nM). It displays potent radioprotective activity and prevents apoptosis of human T cells subjected to ionizing radiation (EC50= 3-7.6µM). Useful tool for dissecting the role of Chk2 in cellular signaling.
UOM: 1 * 10 mg
Image Unavailable-ENZOBMLEI3070005

GW5074 ≥98% (par CCM)

Fournisseur: ENZO LIFE SCIENCES
Description: Potent and selective cell permeable inhibitor of cRAF1 kinase (IC50 = 9 nM) with 100-fold selectivity over CDK1, CDK2, c-src, ERK2, MEK, p38, Tie2, VEGFR2 and c-fm. A useful tool for assessing the involvement of the Ras/Raf-1/ERK pathway in various signaling pathways. Displays neuroprotective effects in vivo through a MEK-ERK and Akt-independent mechanism.

Product Image-GAINSM-1B-6

Cryogenic markers, SCIENCE-MARKER™

Fournisseur: GA
Description: Cryogenic permanent marker with fine tip.

Product Image-WHEAW225700

Accessories for battery powered and high performance crimpers

Fournisseur: DWK Life Sciences
Description: Stand for battery powered crimping tool

Image Unavailable-ENZOALX430049M100

Zinc protoporphyrin ≥95% (par CCM)

Fournisseur: ENZO LIFE SCIENCES
Description: Potent and selective inhibitor of heme oxygenase (Ki=3nM), the enzyme that generates carbon monoxide (CO). Inhibits soluble guanylyl cyclase. Produces a time- and concentration-dependent inactivation of all three isoforms of nitric oxide synthase (IC50=0.8µM, 4.0µM, and 5.0µM for nNOS (NOS I), iNOS (NOS II) and eNOS (NOS III), respectively). Does not cross the blood-brain barrier. An useful tool to elucidate the role of CO in signal transduction and as a neurotransmitter.

Image Unavailable-ENZOBMLEI3680010

STAT3 Inhibitor V, Stattic ≥98% (par CCM)

Fournisseur: ENZO LIFE SCIENCES
Description: Small molecule STAT3-specific inhibitor which blocks activation, dimerization and nuclear translocation via binding to the STAT3 SH2 domain. It is a very useful tool for exploring STAT3-mediated signaling pathways. It blocks LPS-mediated STAT3 tyrosine phosphorylation which leads to inhibition of LPS-mediated IL-1β and IL-6 production. In primary cultures of rat neural stem cells it blocks IL-15-induced differentiation.

Product Image-SCOT286304002

Joints d'agitateur, KPG®, DURAN®

Fournisseur: DWK Life Sciences
Description: DURAN®, verre borosilicaté transparent 3.3

Image Unavailable-ENZOBMLSL2100050

D,L-threo-PDMP hydrochloride ≥98% (par CCM)

Fournisseur: ENZO LIFE SCIENCES
Description: Blocks glucosylation of ceramide by inhibiting UDP-glucose:ceramide glucosyltransferase (glucosylceramide synthetase). Inhibits the expression of cell surface glycolipid antigens and inhibits the growth of cultured rabbit skin fibroblasts. Possesses antitumor activity and inhibits Lewis lung carcinoma cell metastasis in vitro. Useful tool for studying the effects of cellular glycosphingolipid depletion. Enhances the apoptotic response to ionizing radiation by enhancing the ceramide signal.

Image Unavailable-ENZOBML28500500

Cardiotoxicity library, Screen-Well®

Fournisseur: ENZO LIFE SCIENCES
Description: The Screen-Well® cardiotoxicity library is a focused collection of 130 compounds with defined and diverse cardiotoxicity, including ion channel blockage, mitochondrial toxicity, arrhythmia, fibrosis, and many more. A variety of structurally and mechanistically different compound classes are included, as well as nontoxic controls. The compounds are dissolved in DMSO at 10 mM and aliquoted into deep-well plates. The library is an essential tool for predictive toxicology screening and assay development.

Image Unavailable-ENZOBML28510100

Hepatotoxicity library, Screen-Well®

Fournisseur: ENZO LIFE SCIENCES
Description: The Screen-Well® hepatotoxicity library is a focused collection of 238 compounds with defined and diverse hepatotoxicity, including steatosis, mitochondrial toxicity, Mallory body formation, cholestatic effects, and many more. A variety of structurally and mechanistically different compound classes are included, as well as nontoxic controls. The compounds are dissolved in DMSO at 10 mM and aliquoted into deep-well plates. The library is an essential tool for predictive toxicology screening and assay development.

Image Unavailable-ENZOBML28520100

Hematopoietic library, Screen-Well®

Fournisseur: ENZO LIFE SCIENCES
Description: The Screen-Well® hematopoietic toxicity library is a focused collection of 115 compounds with defined and diverse hematopoietic toxicity, including myelosuppression, neutropenia, leukopenia, anaemia, and many more. A variety of structurally and mechanistically different compound classes are included, as well as nontoxic controls. The compounds are dissolved in DMSO at 10 mM and aliquoted into deep-well plates. The library is an essential tool for predictive toxicology screening and assay development.

Product Image-SCOT245004209

DURAN® KPG® Stirrer Bearings

Fournisseur: DWK Life Sciences
Description: DURAN®, clear borosilicate glass 3.3.

Image Unavailable-ENZOBMLEI3960005

Ko143 ≥96% (par HPLC)

Fournisseur: ENZO LIFE SCIENCES
Description: Analog of the fungal toxin fumitremorgin C. Potent and selective inhibitor of the breast cancer resistance protein multidrug transporter (BCRP, EC90=26nM). Highly effective for increasing the intracellular drug accumulation and reversing BCRP-mediated multidrug resistance yet has little activity against P-glycoprotein, multidrug resistance-associated protein (MRP1) and other known drug transporters. In mouse models Ko143 was able to restore the intracellular accumulation and abolish the directionality in net flux of dasatinib. It is a highly useful tool for the identification of drug transport processes in complex experimental systems.

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