Votre recherche pour: ENZO LIFE SCIENCES

Fournisseur: ENZO LIFE SCIENCES

Description: The 70 kDa heat shock protein Hsp70 belongs to the Hsp70 family of highly-related protein isoforms ranging in size from 66 kDa to 78 kDa. Hsc70 shares close biochemical and biological ties to Hsp70, and also belongs to the Hsp70 family. These proteins include cognate members found within major intracellular compartments and highly inducible isoforms predominantly cytoplasmic or nuclear in distribution. Members of the Hsp70 family function as molecular chaperones involved in such cellular functions as protein folding, transport, maturation and degradation, operating in an ATP-dependent manner. The molecular chaperones of the Hsp70 family recognize and bind to nascent polypeptide chains or partially folded intermediates of proteins, preventing their aggregation and misfolding, and the binding of ATP triggers a critical conformational change leading to the release of the bound substrate protein. Data demonstrates that with a ubiquitin-like domain at its amino terminus and its association with the 26S proteosome in HeLa cells, Bag-1 modulates the chaperone activity of Hsc70 and Hsp70. These findings reveal Bag-1's role as a physical link between the Hsc70/Hsp70 chaperone system and the proteasome. Experimental data also shows that the ATPase domain and the substrate-binding domain of Hsp70 (or Hsc70) cooperate to form a co-chaperone-chaperone complex with the synaptic vesicle cysteine string protein (csp), essential for normal neurotransmitter release.

Fournisseur: ENZO LIFE SCIENCES

Description: Cell permeable inhibitor of the 26S proteasome (MCP; multicatalytic proteinase complex) in HT4 cells. Causes accumulation of ubiquitinylated proteins in neuronal cells. Prevents the activation of NF-κB in response to TNF-α or okadaic acid through inhibition of IκBα degradation.

Référence Produit: (ENZOALX522044C050)

Fournisseur: ENZO LIFE SCIENCES

Description: Produced in HEK 293 cells. The cysteine-rich domain of human NGFR (nerve growth factor receptor; p75NTR) (aa 1-250) is fused to the Fc portion of human IgG1.

UOM: 1 * 50 µG

*Promo

Référence Produit: (ENZOBMLAK4130001)

Fournisseur: ENZO LIFE SCIENCES

Description: A QuantiZyme™ Assay System. The MMP-13 Fluorometric (also known as fluorimetric) Drug Discovery Kit is a complete assay system designed to screen inhibitors of matrix metalloproteinase-13 (MMP-13, collagenase-3) using a quenched fluorogenic peptide: OmniMMP™ fluorogenic substrate Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH. Mca fluorescence is quenched by the Dpa group until cleavage by MMPs at the Gly-Leu bond separates the two moieties.

UOM: 1 * 1 KIT

*Promo

Référence Produit: (ENZOBMLS1090005)

Fournisseur: ENZO LIFE SCIENCES

Description: Potent inhibitor of α-mannosidase I. Blocks the biosynthesis of complex-type oligosaccharides. Does not inhibit the biosynthesis of lipid-linked oligosaccharides. Induces ER stress in human cells.

UOM: 1 * 5 mg

*Promo

Référence Produit: (ENZOENZABS1050100)

Fournisseur: ENZO LIFE SCIENCES

Description: Recommended Applications: ICC, IHC, IP, WB, Immunoelectron microscopy

UOM: 1 * 100 µl

*Promo

Référence Produit: (ENZOADIKAMCC210E)

Fournisseur: ENZO LIFE SCIENCES

Description: DNA-topoisomerase II, also known as Topo II or Top 2, is a multifunctional nuclear enzyme required during DNA replication, chromosome disjunction at mitosis, and other DNA-related activities because of its ability to alter DNA supercoiling. In mammalian cells, Topo II consists of two isozymes, Topo II-alpha (170kDa) and Topo II-beta (180kDa) and expression and localization of each isoform are distinct and stage specific during the cell cycle. Topo II-beta is expressed constitutively throughout the cell cycle, whereas the expression of Topo II-alpha is cell cycle-regulated, peaking in G2 to M phase and declining to a minimal level at the end of M phase. DNA-topoisomerase II is the target of some of the most active drugs used in chemotherapy and has been shown to have a critical role in neural development.

UOM: 1 * 100 µG

*Promo

Référence Produit: (ENZOBMLEI3180100)

Fournisseur: ENZO LIFE SCIENCES

Description: Inhibits ergosterol biosynthesis at the level of squalene epoxidase. Potent non-competitive inhibitor of squalene epoxidase from Candida (Ki=30 nM), inhibiting mammalian enzymes at higher concentrations (4-77 µM). It inhibits HUVEC proliferation and angiogenesis and displays interesting anti-inflammatory and free radical scavenging activities. Clinically useful antifungal agent.

UOM: 1 * 100 mg

*Promo

Référence Produit: (ENZOALX209001C050)

Fournisseur: ENZO LIFE SCIENCES

Description: Isolated from bovine brain.

UOM: 1 * 50 µG

*Promo

Fournisseur: ENZO LIFE SCIENCES

Description: NOS inhibitor

Référence Produit: (ENZOADIEKS390A)

Fournisseur: ENZO LIFE SCIENCES

Description: The PKA Kinase activity kit is an efficient assay that utilizes little sample volume. This kit gives you the ability to an end-point or kinetic assay read-out in a convenient 96-well plate based assay and offers easy sample handling protocols. The assay also offers a high signal to background ratio.

UOM: 1 * 1 KIT

*Promo

Fournisseur: ENZO LIFE SCIENCES

Description: Produced in <i>E. coli</i>.

Fournisseur: ENZO LIFE SCIENCES

Description: delta-opioid receptor agonist

Référence Produit: (ENZOBMLGR3350025)

Fournisseur: ENZO LIFE SCIENCES

Description: Negative control for cyclopamine.

UOM: 1 * 25 mg

*Promo

Fournisseur: ENZO LIFE SCIENCES

Description: The Screen-Well® Wnt pathway library v 2.0 is a focused collection of 71 compounds with defined and diverse Wnt pathway activity, including activators and inhibitors of Wnts, Dishevelled, GSK-3β and other Wnt pathway kinases, TCF/β-catenin, DKK, LRP, Axin, Porcupine, and more. Compounds are dissolved in DMSO at 10 mM or 1 mM and aliquoted into deep-well plates at 100 or 500 µl per well. A variety of structurally and mechanistically different compound classes are included. A useful tool for studying the roles of pro- and anti-Wnt pathway molecules in cells as well as for use in<i> in vitro</i> applications.

Référence Produit: (ENZOALX420036M025)

Fournisseur: ENZO LIFE SCIENCES

Description: Inhibitor of caspase-3 and caspase-7 binding to an allosteric site and not to the active site.

UOM: 1 * 25 mg

*Promo