Imprimer

Votre recherche pour: R\u00E9actifs+de+transformation


93 591  résultat(s)

Filtrer les Résultats Trier par
SearchResultCount:"93591"

Sort Results

Vue liste Nouvelle Vue

Evaluer les résultats de votre recherche

Image Unavailable-BOSSBS-11234R-A488

Anti-ZBTB17 Rabbit Polyclonal Antibody (Alexa Fluor® 488)

Référence Produit: (BOSSBS-11234R-A488)
Fournisseur: Bioss
Description: The Myc family, including c-Myc-, N-Myc- and L-Myc, are nuclear proteins with relatively short half lives that contribute an important role in cellular processes such as proliferation, differentiation, apoptosis and transformation. The c-Myc protein activates transcription as part of a heteromeric complex with a number of interacting partners, including Max and Mxi 1; however the transforming properties of the Myc proto-oncogene are believed to be associated with Myc-mediated transcriptional repression. A POZ domain Zn finger protein, designated Miz-1 for Myc-interacting Zn finger protein-1, is a specific target of Myc-induced gene repression. Miz-1 interacts with Myc, but not Max or other Myc partners, and binding of Myc to Miz-1 requires the helix-loop-helix domain of Myc and a short amphipathic helix located in the carboxy-terminus of Miz-1. Miz-1 associates with DNA elements on the adenovirus major late and cyclin D1 promoters and activates transcription of both promoters. Expression of Miz-1 induces potent growth arrest function, and this latency is reversed by the addition of Myc.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-11234R-A350

Anti-ZBTB17 Rabbit Polyclonal Antibody (Alexa Fluor® 350)

Référence Produit: (BOSSBS-11234R-A350)
Fournisseur: Bioss
Description: The Myc family, including c-Myc-, N-Myc- and L-Myc, are nuclear proteins with relatively short half lives that contribute an important role in cellular processes such as proliferation, differentiation, apoptosis and transformation. The c-Myc protein activates transcription as part of a heteromeric complex with a number of interacting partners, including Max and Mxi 1; however the transforming properties of the Myc proto-oncogene are believed to be associated with Myc-mediated transcriptional repression. A POZ domain Zn finger protein, designated Miz-1 for Myc-interacting Zn finger protein-1, is a specific target of Myc-induced gene repression. Miz-1 interacts with Myc, but not Max or other Myc partners, and binding of Myc to Miz-1 requires the helix-loop-helix domain of Myc and a short amphipathic helix located in the carboxy-terminus of Miz-1. Miz-1 associates with DNA elements on the adenovirus major late and cyclin D1 promoters and activates transcription of both promoters. Expression of Miz-1 induces potent growth arrest function, and this latency is reversed by the addition of Myc.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-11251R-CY7

Anti-EPS15 Rabbit Polyclonal Antibody (Cy7®)

Référence Produit: (BOSSBS-11251R-CY7)
Fournisseur: Bioss
Description: Elucidation of the mechanism by which receptor tyrosine kinases (RTKs) modulate cellular physiology in response to stimuli is critical to the understanding of growth regulation. Miscues in RTK signaling pathways can result in cellular transformation and ultimately in cancer. Two novel EGF receptor substrates designated EGF-receptor pathway substrates 8 and 15, or Eps8 and Eps15, have been described. Eps8 and Eps15 are proteins, respectively that become tyrosine phosphorylated subsequent to EGF stimulation. Overexpression of Eps15 in NIH/3T3 cells causes cellular transformation, implying involvement in the regulation of cell proliferation. Eps15 is capable of binding the amino terminal portion of Crk via a conserved proline-rich domain, characteristic of all Crk binding proteins (5). Overexpression of Eps8 in both fibroblasts and hematopoietic cells results in an increased mitogenic response to EGF. Eps8 has been shown to associate with the EGF receptor despite its lack of a functional SH2 domain. Further characterization suggests the protein has both a PH domain and a SH3 domain, the functional significance of which are not yet known.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-3755R-A488

Anti-CRKL Rabbit Polyclonal Antibody (Alexa Fluor® 488)

Référence Produit: (BOSSBS-3755R-A488)
Fournisseur: Bioss
Description: Crkl is a 34kDa adaptor protein which has been shown to activate the RAS and JUN kinase signalling pathways and transforms fibroblasts in a RAS dependant manner. Crkl is a substitute of BCR ABL tyrosine kinase. In addition, Crkl has oncogenic potential.
UOM: 1 * 100 µl
Image Unavailable-BNC940642-100

Anti-EGFR Mouse Monoclonal Antibody (CF594) [clone: H9B4]

Fournisseur: Biotium
Description: This MAb reacts with a cytoplasmic domain of EGFR. EGFR is a type I receptor tyrosine kinase with sequence homology to erbB-1, -2, -3 -4 or HER-1, -2, -3 -4. It binds to Epidermal Growth Factor (EGF), Transforming Growth Factor-a (TGF-a), Heparin-binding EGF (HB-EGF), amphiregulin, βcellulin & epiregulin.

Image Unavailable-BNC040642-500

Anti-EGFR Mouse Monoclonal Antibody (CF405S) [clone: H9B4]

Fournisseur: Biotium
Description: This MAb reacts with a cytoplasmic domain of EGFR. EGFR is a type I receptor tyrosine kinase with sequence homology to erbB-1, -2, -3 -4 or HER-1, -2, -3 -4. It binds to Epidermal Growth Factor (EGF), Transforming Growth Factor-a (TGF-a), Heparin-binding EGF (HB-EGF), amphiregulin, βcellulin & epiregulin.

Image Unavailable-BOSSBS-0480R-A488

Anti-IFNG Rabbit Polyclonal Antibody (Alexa Fluor® 488)

Référence Produit: (BOSSBS-0480R-A488)
Fournisseur: Bioss
Description: Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-0481R-A555

Anti-IFNG Rabbit Polyclonal Antibody (Alexa Fluor® 555)

Référence Produit: (BOSSBS-0481R-A555)
Fournisseur: Bioss
Description: Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-6874R-A350

Anti-CAT Rabbit Polyclonal Antibody (Alexa Fluor® 350)

Référence Produit: (BOSSBS-6874R-A350)
Fournisseur: Bioss
Description: Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Promotes growth of cells including T-cells, B-cells, myeloid leukemia cells, melanoma cells, mastocytoma cells and normal and transformed fibroblast cells.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-1684R-CY5

Anti-SKI Rabbit Polyclonal Antibody (Cy5®)

Référence Produit: (BOSSBS-1684R-CY5)
Fournisseur: Bioss
Description: SKI is a nuclear protein that forms homodimers and heterodimers and binds to DNA to function as transcriptional activators and repressors. The SKI oncoprotein dramatically affects cell growth, differentiation, and/or survival. SKI was shown to act in distinct signaling pathways including those involving nuclear receptors, transforming growth factor beta, and tumor suppressors. SKI inhibits transforming growth factor-beta (TGF-beta) signaling through interaction with Smad proteins. SKI represses Smad-mediated transcriptional activation, probably through its action as a transcriptional co-repressor. SKI also inhibits TGF-beta-induced downregulation of genes such as c-myc.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-1684R-HRP

Anti-SKI Rabbit Polyclonal Antibody (HRP (Horseradish Peroxidase))

Référence Produit: (BOSSBS-1684R-HRP)
Fournisseur: Bioss
Description: SKI is a nuclear protein that forms homodimers and heterodimers and binds to DNA to function as transcriptional activators and repressors. The SKI oncoprotein dramatically affects cell growth, differentiation, and/or survival. SKI was shown to act in distinct signaling pathways including those involving nuclear receptors, transforming growth factor beta, and tumor suppressors. SKI inhibits transforming growth factor-beta (TGF-beta) signaling through interaction with Smad proteins. SKI represses Smad-mediated transcriptional activation, probably through its action as a transcriptional co-repressor. SKI also inhibits TGF-beta-induced downregulation of genes such as c-myc.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-2969R-CY5.5

Anti-HPV33 E7 Rabbit Polyclonal Antibody (Cy5.5®)

Référence Produit: (BOSSBS-2969R-CY5.5)
Fournisseur: Bioss
Description: E7 protein has both transforming and trans-activating activities. Disrupts the function of host retinoblastoma protein RB1/pRb, which is a key regulator of the cell cycle. Induces the disassembly of the E2F1 transcription factors from RB1, with subsequent transcriptional activation of E2F1-regulated S-phase genes. Inactivation of the ability of RB1 to arrest the cell cycle is critical for cellular transformation, uncontrolled cellular growth and proliferation induced by viral infection. Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery to achieve viral genome replication. Interferes with histone deacetylation mediated by HDAC1 and HDAC2, leading to activation of transcription (By similarity).
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-6165R

Anti-HRAS Rabbit Polyclonal Antibody

Référence Produit: (BOSSBS-6165R)
Fournisseur: Bioss
Description: The KRAS gene encodes the human cellular homolog of a transforming gene isolated from the Kirsten rat sarcoma virus. The RAS proteins are GDP/GTP-binding proteins that act as intracellular signal transducers. The most well-studied members of the RAS (derived from 'RAt Sarcoma' virus) gene family include KRAS, HRAS, and NRAS. These genes encode immunologically related proteins with a molecular mass of 21 kD and are homologs of rodent sarcoma virus genes that have transforming abilities. While these wildtype cellular proteins in humans play a vital role in normal tissue signaling, including proliferation, differentiation, and senescence, mutated genes are potent oncogenes that play a role in many human cancers.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-0817R-A680

Anti-MAGE-1 Rabbit Polyclonal Antibody (Alexa Fluor® 680)

Référence Produit: (BOSSBS-0817R-A680)
Fournisseur: Bioss
Description: May be involved in transcriptional regulation through interaction with SNW1 and recruiting histone deactelyase HDAC1. May inhibit notch intracellular domain (NICD) transactivation. May play a role in embryonal development and tumor transformation or aspects of tumor progression. Antigen recognised on a melanoma by autologous cytolytic T-lymphocytes.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-5957R-FITC

Anti-STYK1 Rabbit Polyclonal Antibody (FITC (Fluorescein Isothiocyanate))

Référence Produit: (BOSSBS-5957R-FITC)
Fournisseur: Bioss
Description: Probable tyrosine protein-kinase, which has strong transforming capabilities on a variety of cell lines. When overexpressed, it can also induce tumor cell invasion as well as metastasis in distant organs. May act by activating both MAP kinase and phosphatidylinositol 3'-kinases (PI3K) pathways (By similarity).
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-6818R-A488

Anti-MAGEA12 Rabbit Polyclonal Antibody (Alexa Fluor® 488)

Référence Produit: (BOSSBS-6818R-A488)
Fournisseur: Bioss
Description: Not known, though may play a role in tumor transformation or aspects of tumor progression.Tissue specificity: Expressed in many tumors of several types, such as melanoma, head and neck squamous cell carcinoma, lung carcinoma and breast carcinoma, but not in normal tissues except for testes.
UOM: 1 * 100 µl
Prix sur demande
Le stock de cet article est limité mais peut être disponible dans un entrepôt proche de vous. Merci de vous assurer que vous êtes connecté sur le site afin que le stock disponible soit affiché. Si l'call est toujours affiché et vous avez besoin d'aide, s'il vous plaît appelez-nous au 01 45 14 89 12.
Le stock de cet article est limité mais peut être disponible dans un entrepôt proche de vous. Merci de vous assurer que vous êtes connecté sur le site afin que le stock disponible soit affiché. Si l'call est toujours affiché et vous avez besoin d'aide, s'il vous plaît appelez-nous au 01 45 14 89 12.
Ces articles ne peuvent pas être ajoutés à votre panier en raison des exigences réglementaires. Veuillez envoyer un e-mail à webshop.fr@vwr.com
Veuillez noter qu'une autorisation peut être nécessaire pour commander ce produit. Un représentant de VWR vous contactera si votre commande le nécessite.
Ce produit a été bloqué par votre entreprise. Veuillez s'il vous plait contacter votre service achats pour plus d'informations.
Le produit original n'est plus disponible. Le remplacement représenté est disponible
Ce produit n'est plus disponible. Des alternatives peuvent être disponibles en faisant une recherche avec la référence VWR ci-dessus. Si vous avez besoin d'aide, s'il vous plaît appelez le Service Clients au 0825 02 30 30 (0,18 € TTC/mn).
401 - 416 of 93 591
no targeter for Bottom