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Ko143 ≥96% (par HPLC)

Fournisseur: ENZO LIFE SCIENCES
Description: Analog of the fungal toxin fumitremorgin C. Potent and selective inhibitor of the breast cancer resistance protein multidrug transporter (BCRP, EC90=26nM). Highly effective for increasing the intracellular drug accumulation and reversing BCRP-mediated multidrug resistance yet has little activity against P-glycoprotein, multidrug resistance-associated protein (MRP1) and other known drug transporters. In mouse models Ko143 was able to restore the intracellular accumulation and abolish the directionality in net flux of dasatinib. It is a highly useful tool for the identification of drug transport processes in complex experimental systems.

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Hematopoietic library, Screen-Well®

Fournisseur: ENZO LIFE SCIENCES
Description: The Screen-Well® hematopoietic toxicity library is a focused collection of 115 compounds with defined and diverse hematopoietic toxicity, including myelosuppression, neutropenia, leukopenia, anaemia, and many more. A variety of structurally and mechanistically different compound classes are included, as well as nontoxic controls. The compounds are dissolved in DMSO at 10 mM and aliquoted into deep-well plates. The library is an essential tool for predictive toxicology screening and assay development.

Product Image-SCERSP15115-24

Pycnometer, Le Chatelier, class A, serialised, KIMAX®

Référence Produit: (SCERSP15115-24)
Fournisseur: DWK Life Sciences
Description: KIMAX® bottle is used to determine the specific gravity of cement, sand, and other fine materials (ASTM C188).
UOM: 1 * 1 Pce
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Nω-Methyl-L-arginine monoacetate ≥99% (par CCM)

Fournisseur: ENZO LIFE SCIENCES
Description: Competitively inhibits the generation of NO from arginine and is a useful tool for inhibition of NO mediated effects. In vitro, L-NMMA inhibits relaxation of rat aorta rings induced by acetylcholine (IC50=9.5µM). In vivo, it causes a dose dependent increase in mean arterial blood pressure in anesthetized rats (EC50=16.7mg/kg).

Product Image-WHEAW225830-D

High performance crimping tool and jaw sets, WHEATON®

Fournisseur: DWK Life Sciences
Description: These high performance crimping tools are designed with inter-changeable jaws, so that users only need one tool, and can purchase individually sized crimpers and decappers for specific laboratory requirements.

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PD 98059 ≥95% (par HPLC)

Référence Produit: (ENZOBMLEI3600005)
Fournisseur: ENZO LIFE SCIENCES
Description: PD-98059 is a potent and selective inhibitor of MAP kinase kinase (MEK). It selectively blocks the activation of MEK thereby inhibiting the phosphorylation and the activation of MAP kinase. PD-98059 is cell permeable. In PC12 pheochromocytoma cells, it completely blocked the increase in MAP kinase activity produced by NGF, IC50=2µM. Enhances self-renewal of embryonic stem cells PD-98059 is an invaluable tool to help elucidate the role of the MAPK cascade in a variety of biological systems. Inhibits cell growth and proliferation in acute myelogenous leukemia cell lines by causing cell arrest.
UOM: 1 * 5 mg
Product Image-SCOT245405103

Stirrer bearings, DURAN® KPG®

Fournisseur: DWK Life Sciences
Description: DURAN®, clear borosilicate glass 3.3.

Product Image-SCOT247500906

Roulements d'agitation KPG avec filetage de vis

Fournisseur: DWK Life Sciences
Description: DURAN®, clear borosilicate glass 3.3.

Product Image-MICRITCAW-9

Outils de nettoyage pour isolateurs

Fournisseur: MICRONOVA
Description: L'adaptateur Isolator Tool ™ avec un pivot à 360 ° fonctionne avec une gamme de housses de vadrouille pour nettoyer et désinfecter efficacement les isolateurs, les hottes, le RABS et le petit équipement dans les zones propres et aseptiques.

Environmentally Preferable

Product Image-630-1936

VWR® VisiScope® TL384 POL, Microscope de polarisation

Référence Produit: (630-1936)
Fournisseur: VWR Collection
Description: Microscope droit pour les observations en fond clair et en lumière polarisante avec objectifs IOS N-plan POL sans contrainte. Parfait pour une analyse de polarisation précise en biologie et en science des matériaux.
UOM: 1 * 1 Pce
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Nephrotoxicity library, Screen-Well®

Référence Produit: (ENZOENZLIB1000100)
Fournisseur: ENZO LIFE SCIENCES
Description: The Screen-Well® nephrotoxicity library is a focused collection of 86 compounds with defined and diverse nephrotoxicity, including analgesic nephropathy, interstitial nephritis, glomerularopathy, proximal and distal tubulopathy, acute renal failure, chronic kidney disease, and more. A variety of structurally and mechanistically different compound classes are included, as well as nontoxic controls. Most of the compounds are dissolved in DMSO at 10 mM unless otherwise stated in the documentation provided with the library. Selected compounds are dissolved in DI water. All compounds are provided at 100 μl volumes in a 96-well plate. This library is an essential cost-effective tool for predictive toxicology screening and assay development.
UOM: 1 * 1 SET
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Robinets de burettes, droits, coudés, DURAN®

Référence Produit: (SCOT286451205)
Fournisseur: DWK Life Sciences
Description: DURAN®, verre borosilicaté 3,3, transparent, rodé finement, sans clés.
UOM: 1 * 50 Pce
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Epigenetics library, Screen-Well®

Fournisseur: ENZO LIFE SCIENCES
Description: The Screen-Well® epigenetics library contains 43 compounds with defined activity against enzymes which carry out epigenetic modification of lysine. It also includes DNA methylation inhibitors. Compounds are dissolved in DMSO at 10 mM and aliquoted into deep-well plates at 100 µl or 500 µl per well. The library is a useful tool for chemical genomics, assay development and other pharmacological applications. The library contains inhibitors of these important enzymes: HDACs, SIRTs, Lysine demethylases, HATs, Histone methyl transferases, DNA methyltransferases as well as SIRT activators. A variety of structurally and mechanistically different compound classes are included.

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Wnt pathway library, Screen-Well®

Fournisseur: ENZO LIFE SCIENCES
Description: The Screen-Well® Wnt pathway library v 2.0 is a focused collection of 71 compounds with defined and diverse Wnt pathway activity, including activators and inhibitors of Wnts, Dishevelled, GSK-3β and other Wnt pathway kinases, TCF/β-catenin, DKK, LRP, Axin, Porcupine, and more. Compounds are dissolved in DMSO at 10 mM or 1 mM and aliquoted into deep-well plates at 100 or 500 µl per well. A variety of structurally and mechanistically different compound classes are included. A useful tool for studying the roles of pro- and anti-Wnt pathway molecules in cells as well as for use in<i> in vitro</i> applications.

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Kinase inhibitor library, Screen-Well®

Fournisseur: ENZO LIFE SCIENCES
Description: The Screen-Well™ Kinase Inhibitor Library contains 80 known kinase inhibitors of well-defined activity. Inhibitors are supplied dissolved in DMSO at 10 mM and aliquoted into deep-well plates at either 100 or 500 ml per well. The library is an ideal tool for chemical genomics, assay development and other pharmacological applications. Includes inhibitors of these important kinases: Insulin/IGF Receptors, PI 3-Kinase, CaM Kinase II, JAK, PKA, CDK, JNK, PKC, CKI II, MAPK, RAF, EGFR, MEK, SAPK, GSK, MLCK, Src-family, IKK, PDGFR, VEGFR and many more.

Product Image-WHEAW225814

WHEATON® Battery Powered Crimpers and Decappers

Fournisseur: DWK Life Sciences
Description: These battery powered crimpers and decappers fit standard laboratory vials and seals. They come with a long-lasting battery with lithium ion technology, which allows for up to 800 crimps per charge.

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Le stock de cet article est limité mais peut être disponible dans un entrepôt proche de vous. Merci de vous assurer que vous êtes connecté sur le site afin que le stock disponible soit affiché. Si l'call est toujours affiché et vous avez besoin d'aide, s'il vous plaît appelez-nous au 01 45 14 89 12.
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Ce produit n'est plus disponible. Des alternatives peuvent être disponibles en faisant une recherche avec la référence VWR ci-dessus. Si vous avez besoin d'aide, s'il vous plaît appelez le Service Clients au 0825 02 30 30 (0,18 € TTC/mn).
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