Description: Human beta-Lipotropin is a 93 amino acid polypeptide that is cleaved from carboxy-terminal fragment of the precursor pro-opiomelanocortin (POMC). It stimulates melanocytes to produce melanin, and can also be cleaved into smaller peptides including opioid peptides: gamma-lipotropin, alpha-MSH, beta-MSH, gamma-MSH, alpha-endorphin, beta-endorphin, gamma-endorphin and met-enkephalin

Référence Produit: BSENR-1493-50

UOM: 1 * 50 µG

Fournisseur: Biosensis

*Promo

Description: Adrenocorticotropic hormone (ACTH) is cleaved from the precursor pro-opiomelanocortin (POMC). The hormone is produced and secreted by the pituitary gland and stimulates release of cortisol by adrenal glands.

Référence Produit: BSENR-1491-50

UOM: 1 * 50 µG

Fournisseur: Biosensis

*Promo

Description: High-mobility group proteins were named originally since they are abundand relatively low molecular weight proteins which run quickly on SDS-PAGE gels. High-mobility group protein box 1 (HMGB1, Amphoterin) is one of these. The "bx" in the name refers to the so-called high mobility group (HMG) box, a compact domain involved in DNA binding and protein-protein interactions. the HMGB1 molecule has two of these HMG domains. The protein is alslo called amphoterin, this name being derived from the presence of two highly charged regions in the molecule, a relatively neutrally charged N-terminus and a very negatively charged C-terminus. In fact the molecule is very unusually charged throughout, the human sequence consisting of 16.7% Glutamic acid, 9.3% Aspartic acid, 20% lysine and 9.3% Arginine. HMGB1 can bind Toll like receptor 4 (TLR4) and the Receptor for Advanced Glycation End products (RAGE). TLRs are components of the innate immune system, first recognized as a family of receptors which recognize "Pathogen Associated Molecular Pattern molecules (PAMPs). PAMPs are common components of bacteria and when TLRs bind these a strong inflammatory response is activated. More recently it has been recognized that TLRs can also be activated by Damage Associated Molecular Pattern molecules (DAMPs), which are endogenous substances released from damaged and diseased cells which also bind to TLR family receptors and also activate inflammation. HMGB1 is such a DAMP, binding to TLR4, and much evidence suggests that HMGB1 is a strong activator of inflammation. Interestingly, HMGB1 is released by necrotic cells but not by apoptotic cells (1).

Référence Produit: BSENM-1702-100

UOM: 1 * 100 µl

Fournisseur: Biosensis

*Promo

Description: Recognizes native and denatured forms of Cyan Fluorescent Protein (CFP) and its variants: Enhanced Green Fluorescent Protein (EGFP), Yellow Fluorescent Protein (YFP), Enhanced Yellow Fluorescent Protein (EYFP) and Cyan Fluorescent Protein (CFP).

Référence Produit: BSENM-1300-100

UOM: 1 * 100 µG

Fournisseur: Biosensis

*Promo

Description: Designed to detect Red Fluorescent Protein (RFP) and its variants in ELISA (sandwich or capture), immunoblotting, immunoprecipitation and immunohistochemistry.

Référence Produit: BSENM-1315-100

UOM: 1 * 100 µG

Fournisseur: Biosensis

*Promo

Description: Presenilin-1 (PSEN1) is a multi-pass membrane protein and component of the gamma-secretase complex. PSEN1 is thought to play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. It may also play a role in hematopoiesis. Defects in PSEN1 are a cause of Alzheimer disease type 3 (AD3), a familial early-onset form of Alzheimer disease (Ref:SWISS-Prot).

Référence Produit: BSENR-1605-500

UOM: 1 * 500 µG

Fournisseur: Biosensis

*Promo

Description: GFAP is a 50 kDa intra-cytoplasmic filamentous protein of the cytoskeleton in astrocytes. During the development of the central nervous system, it is a cell-specific marker that distinguishes astrocytes from other glial cells. GFAP immunoreactivity has been shown in immature oligodendrocytes, epiglottic cartilage, pituicytes, papillary meningiomas, myoepithelial cells of the breast and in non-CNS: Schwann cells, salivary gland neoplasms, enteric glia cells, and metastasizing renal carcinomas.

Référence Produit: BSENM-1375-100

UOM: 1 * 100 µl

Fournisseur: Biosensis

*Promo

Description: Nicastrin, a type 1 membrane glycoprotein, is an essential component of the gamma secretase complex which is critical for the cleavage of the amyloid precursor protein and other membrane proteins. Nicastrin is widely expressed in different tissue types. This antibody detects all processed forms of Nicastrin.

Référence Produit: BSENR-1684-500

UOM: 1 * 500 µG

Fournisseur: Biosensis

*Promo

Description: FUNCTION: Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. It stimulates division and differentiation of sympathetic and embryonic sensory neurons. SUBUNIT: Homodimer, associated by noncovalent forces. SUBCELLULAR LOCATION: Secreted protein. SIMILARITY: Belongs to the NGF-beta family.

Référence Produit: BSENR-093-500

UOM: 1 * 500 µG

Fournisseur: Biosensis

*Promo

Description: BDNF belongs to the neurotrophin family and regulates the survival and differentiation of neurons during development. The alterations in BDNF expression induced by various kinds of brain insult including stress, ischemia, seizure activity and hypoglycemia, may contribute to some pathologies such as depression, epilepsy, Alzheimer's, and Parkinson's disease. Microglia release BDNF that may contribute to neuroinflammation and neuropathic pain.FUNCTION: Promotes the survival of neuronal populations that are all located either in the central nervous system or directly connected to it. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability. SUBUNIT: Monomers and homodimers. Binds to NTRK2/TRKB. SUBCELLULAR LOCATION: Secreted protein. POst translation modification: Converted into mature BDNF by plasmin (PLG). SIMILARITY: Belongs to the NGF-beta family.

Référence Produit: BSENR-066-500

UOM: 1 * 500 µG

Fournisseur: Biosensis

*Promo

Description: The Biosensis CE Marked BDNF Rapid™ enzyme-linked immunosorbent assay (ELISA) Kit is a sandwich ELISA that allows the preferential quantification of mature BDNF in less than 3 hours. This kit consists of a pre-coated mouse monoclonal anti-BDNF capture antibody, a biotinylated anti-BDNF detection antibody and horseradish peroxidase (HRP)-conjugated streptavidin. The addition of a substrate (3,3’,5,5’- tetramethylbenzidine, TMB) yields a coloured reaction product which is directly proportional to the concentration of BDNF present in samples and protein standards.

Référence Produit: BSENBEK-2211-1P-CE

UOM: 1 * 96 Tests

Fournisseur: Biosensis

*Promo

Description: Amylo-Glo RTD reagent is designed to stain amyloid plaques in tissue sections.

Référence Produit: BSENTR-300-AG

UOM: 1 * 1 KIT

Fournisseur: Biosensis

*Promo

Description: Anti-LMNA Mouse T4 Antibody [clone: 4C4]

Référence Produit: BSENM-1689-100

UOM: 1 * 100 µG

Fournisseur: Biosensis

*Promo

Description: Anti-ACTA Mouse T4 Antibody [clone: 5J11]

Référence Produit: BSENM-1646-100

UOM: 1 * 100 µG

Fournisseur: Biosensis

*Promo

Description: Anti-TrkB (phospho Y816/Y817) Rabbit Polyclonal Antibody

Référence Produit: BSENR-1717-50

UOM: 1 * 50 µG

Fournisseur: Biosensis

*Promo

Description: The Biosensis Mature BDNF/proBDNF Combo RapidTM enzyme-linked immunosorbent assay (ELISA) Kit combines individual, but complementary ELISA kits for the two most important BDNF isoforms: Mature BDNF (BSENBEK-2211) and full-length proBDNF (BSENBEK-2217).

Référence Produit: BSENBEK-2240-2P

UOM: 1 * 192 Tests

Fournisseur: Biosensis

*Promo