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Mouse Recombinant IL-4 (from E. coli)

Fournisseur: Shenandoah Biotechnology
Description: Interleukin 4 (IL-4) is an immunomodulatory cytokine that functions to induce naïve helper T cells to differentiate into type 2 T helper (Th2) cells. Th2 cells subsequently produce more IL-4 in a positive feedback loop. IL-4 also promotes immunoglobulin IgG to IgE isotype switching on B cells. IL-4 binds the IL-4Rα receptor to activate STAT6 signaling.

Product Image-SHBT100-30AF-1MG

Human Recombinant GALECTIN-1 (Animal free) (from E. coli)

Fournisseur: Shenandoah Biotechnology
Description: Neurotrophin-4 (NT-4) is an important member of the nerve growth factor (NGF) family of proteins. Neurotrophins undergo paracrine and autocrine signaling to control neuronal survival, neuronal differentiation, and dendrite outgrowth. NT-4 is expressed ubiquitously and signals through the TrkB receptor tryrosine kinase.

Product Image-SHBT200-32AF-10UG

Mouse Recombinant TPO (Animal free) (from E. coli)

Fournisseur: Shenandoah Biotechnology
Description: Exodus-2, also known as CCL21 and 6Ckine, is a chemokine that is strongly produced in the human lymph nodes and spleen. Exodus-2 signals through the chemokine receptor CCR7 to regulate thymocyte and activated T cell migration. Exodus-2 also mediates the homing of lymphocytes to the lymphatic system. Human and mouse Exodus-2 proteins share greater than 85% amino acid sequence identity.

Product Image-SHBT100-111AF-1MG

Human Recombinant TNF-A (Animal free) (from E. coli)

Fournisseur: Shenandoah Biotechnology
Description: Tumor necrosis factor alpha (TNF-α) is an inflammatory cytokine secreted by macrophages, monocytes, neutrophils, T cells, and NK-cells following stimulation by bacterial lipopolysaccharide (LPS).

Product Image-SHBT200-53-5UG

Mouse Recombinant EGF (from E. coli)

Fournisseur: Shenandoah Biotechnology
Description: Epidermal growth factor (EGF) is a growth factor that stimulates the proliferation, differentiation, and survival of epithelial and epidermal cells. EGF contains three intramolecular disulfide bonds and binds in high affinity to the epidermal growth factor receptor (EGFR).

FDS (Fiche de données de sécurité)

Product Image-SHBT200-53AF-5UG

Mouse Recombinant EGF (from E. coli)

Fournisseur: Shenandoah Biotechnology
Description: Epidermal growth factor (EGF) is a growth factor that stimulates the proliferation, differentiation, and survival of epithelial and epidermal cells. EGF contains three intramolecular disulfide bonds and binds in high affinity to the epidermal growth factor receptor (EGFR).

Product Image-SHBT100-162AF-100U

Human Recombinant EBI3 (Animal free) (from E. coli)

Fournisseur: Shenandoah Biotechnology
Description: Epstein-Barr virus induced gene-3 (EBI3) is a secreted glycoprotein belonging to the hematopoietin receptor family related to the p40 subunit of interleukin 12 (IL-12). EBI3 expression is induced in B-lymphocytes in response to Epstein-Barr virus infection. EBI3 forms heterodimers with p28 to form interleukin 27 (IL-27), and with p35 to form interleukin 35 (IL-35). Both IL-27 and IL-35 have anti-inflammatory and regulatory activity.

Product Image-SHBT100-77AF-250UG

Human Recombinant IFNg (Animal free) (from E. coli)

Fournisseur: Shenandoah Biotechnology
Description: Interferon gamma (IFN-γ) is a type II interferon that is critical during adaptive and innate immune responses to infection. IFN-γ is produced by T cells and natural killer cells following antigen-specific activation. IFN-γ binds IFN-γ receptors (IFN-γ R1 and IFN-γ R2), which are expressed on most immune cells, to activate the JAK-STAT pathway. IFN-γ-induced signaling increases the expression of class 1 major histocompatibility complex (MHC) molecules. Human IFN-γ is not cross-reactive with mouse IFN-γ.

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Human Recombinant BAFF (Animal free) (from E. coli)

Fournisseur: Shenandoah Biotechnology
Description: B cell-attracting chemokine 1 (BCA-1), also known as CXCL13, is expressed at high levels in lymphoid tissues, such as the spleen, lymph nodes, and Peyer's patches.  BCA-1 activates signaling through the receptor Burkitt lymphoma receptor 1 (BLR1) to chemoattract B cells.

New Product

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Human Recombinant IL-10 (CTGrade GMP) (from E. coli)

Fournisseur: Shenandoah Biotechnology
Description: IL-10 is an anti-inflammatory cytokine produced by macrophages and type 2 T helper (Th2) cells.

New Product

Image Unavailable-SHBTPB-500-10

Mouse T Regulatory Cell Polarizing Recombinant Protein Bundle (rm IL-2, rh TGF-β 1) (from E. coli)

Référence Produit: (SHBTPB-500-10)
Fournisseur: Shenandoah Biotechnology
Description: Cytokines for polarizing T cells into T regulatory cells. T regulatory cells (Tregs) are a subset of T cells that suppress immune function. They are characterized by the expression of CD4, CD25 and Foxp3 and are known to produce immunosuppressive cytokines TGF-β 1 and IL-10. Tregs can be cultured from naive CD4+ T cells by culturing them in the presence of IL-2 and TGF-β 1 with CD3 and CD28 stimulation. In some cases cells are also cultured with neutralizing antibodies to IL-4, IFNγ and IL-12 and/or retinoic acid.
UOM: 1 * 1 KIT

New Product


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Human Recombinant Human Hsc Expansion PB (from E. coli)

Référence Produit: (SHBTPB-500-03)
Fournisseur: Shenandoah Biotechnology
Description: Cytokines for expansion and cell culture of human hematopoietic stem cells. Hematopoietic stem cells are self renewing pluripotent cells often characterised by the expression of CD34. Studies have shown that decreased expression of CD34 tends to correlate with decreased self renewal properties and pluripotent potential. Culturing CD34+ cells in a cytokine mixture of TPO, SCF, and FLT-3 Ligand for short time periods allows CD34+ cells to proliferate without decreasing CD34 expression, thus retaining their stem cell properties. The combination of these cytokines allows for the <i>ex vivo</i> expansion of the most immature hematopoietic stem cells in cord blood or bone marrow preparations, but can be supplemented with other cytokines to promote specific lineages. For example, GM-CSF and/or G-CSF can be added to promote monocytes and granulocytes while EPO can be added to promote erthroid cells.
UOM: 1 * 1 KIT

New Product


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Human Recombinant IL-34 (from CHO cells)

Fournisseur: Shenandoah Biotechnology
Description: Interleukin 34 (IL-34) was originally identified in humans, by large scale screening of secreted proteins; orthologs have also been found in chimpanzee, murine, rat and chicken. Human IL-34 is synthesized as a 242 amino acid (aa) precursor that contains a 20 aa signal sequence and a 222 aa mature chain. IL-34 is secreted as a homodimer and contains one potential N-glycosylation site.  IL-34 increases proliferation of immune cells known as monocytes; it elicits its activity by binding the Colony Stimulating Factor 1 Receptor (CSF-1R). Expression of IL-34 is most abundant in the spleen and is expressed in many other tissues including the heart, brain, liver, kidney, thymus, intestine and lung. Human IL-34 contains a C-terminal 6x-polyhistidine (6xHis) tag. 

Product Image-SHBT100-59-5UG

Human Recombinant CNTF (from E. coli)

Fournisseur: Shenandoah Biotechnology
Description: Ciliary neurotrophic factor (CNTF) is a neurotrophic factor that promotes the survival of neuronal cell populations, neurite outgrowth, and neurotransmitter synthesis.CNTF also plays an important protective role during nervous system injury.

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Human Recombinant SDF-1 B/CXCL12 (from E. coli)

Fournisseur: Shenandoah Biotechnology
Description: Cytokines for the differentation of human monycyte-derived dendritic cells. Dendritic cells are an important type of immune cell that function to activate T and B cells via their role as an antigen presenting cell. Monocytes isolated from peripheral blood can be differentiated to immature dendritic cells (iDCs) through culturing in the presence of interleukin-4 (IL-4) and granulocyte-macrophage colony stimulating factor (GM-CSF).

Product Image-SHBT100-83AF-10UG

Human Recombinant IL-10 (from E. coli)

Fournisseur: Shenandoah Biotechnology
Description: Interleukin 10 (IL-10) is an anti-inflammatory cytokine produced by macrophages and type 2 T helper (Th2) cells. IL-10 inhibits the production of pro-inflammatory cytokines such as interferon gamma (IFN-ɣ), tumor necrosis factor alpha (TNF-α), interleukin 2 (IL-2), interleukin 3 (IL-3), interleukin 4 (IL-4), and granulocyte-macrophage colony-stimulating factor (GM-CSF), made by macrophages and regulatory T cells. IL-10 also suppresses antigen presentation on antigen presenting cells, and enhances the survival, proliferation, and antibody production of B cells. Human IL-10 can act on murine cells, while murine IL-10 is not active on human cells.

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