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JK 184 ≥99% (par HPLC)

Référence Produit: (ENZOENZCHM1290005)
Fournisseur: ENZO LIFE SCIENCES
Description: Hedgehog (Hh) pathway blocker.
UOM: 1 * 5 mg
Image Unavailable-ENZOADI950010100

Fixation/Permeabilisation, (buffer)

Référence Produit: (ENZOADI950010100)
Fournisseur: ENZO LIFE SCIENCES
Description: Fixation/Permeabilization, (buffer)
UOM: 1 * 100 mL
Image Unavailable-ENZOADI920001

PGE2 FPIA kit

Référence Produit: (ENZOADI920001)
Fournisseur: ENZO LIFE SCIENCES
Description: For the quantitative determination of PGE2 in culture supernatants from any species.
UOM: 1 * 100 Tests
Image Unavailable-ENZOADI930001

PGE2 high sensitivity ELISA kit, plasma

Référence Produit: (ENZOADI930001)
Fournisseur: ENZO LIFE SCIENCES
Description: Ultrasensitive PGE2 ELISA kit for inflammation and eicosanoid research.
UOM: 1 * 1 KIT
Image Unavailable-ENZOADI908066010

Human recombinant TNF alpha (1) (from E. coli)

Référence Produit: (ENZOADI908066010)
Fournisseur: ENZO LIFE SCIENCES
Description: Produced in <i>E.coli</i>.
UOM: 1 * 10 µG
Product Image-ENZOADI906001

Chemiluminescent acridinium esters

Fournisseur: ENZO LIFE SCIENCES
Description: Chemiluminescent acridinium esters are commonly used to label antibodies, proteins, nucleic acids, and some peptides, and are frequently used as detection reagents in immunoassays.

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Anti-CD40 Rabbit Polyclonal Antibody

Fournisseur: ENZO LIFE SCIENCES
Description: CD40 is a 45-50 kDa type I membrane protein and a member of the tumor necrosis factor (TNF) receptor superfamily. CD40 is also known as pb50 or CDW40.  CD40 is expressed primarily by professional antigen-presenting cells and it is also expressed on non-immune cell types. The CD40 expressed by professional antigen-presenting cells plays a critical role in co-stimulation and antigen-presenting cell activation in T cell-dependent immune responses. Signals generated through CD40 in B cells are anti-apoptotic. These signals are also required for T cell-dependent B cell activation and proliferation, isotype switching, up-regulation of costimulatory receptors, germinal center formation and memory generation. CD40 signal transduction is initiated by binding trimeric CD40 ligand (CD40L) which is found on the surface of activated T cells.  CD40 engages several signalling pathways in B cells and these include NF-kB, the mitogen-activated protein kinases p38 and c-Jun N-terminal kinase. The 62 amino acid cytoplasmic domain (CD40c) of CD40 contains two linear TNF-receptor associated factor (TRAF) binding domains. The membrane proximal site of CD40c binds TRAF6 and the membrane distal site binds TRAF1, 2 and 3. CD40c is thought to mediate the CD40-dependant signalling pathways by recruitment of TRAF to this multimerized domain. CD40 ligation has also been shown to stimulate iNOS expression, and therefore NO production, by activating NF-kB in IFN-g treated microglial cells. NO derived from microglia has been implicated in the damage of myelin-producing oligodendrocytes in demyelinating disorders like multiple sclerosis (MS) and neuronal death during Alzheimer’s disease and brain trauma. Increased CD40-CD40 ligation has been implicated in the pathogenesis of several autoimmune inflammatory diseases, such as MS, arthritis and insulin-dependant diabetes.

Image Unavailable-ENZOADIAPR1000050

Human recombinant Lc3-I,HIS Tag

Fournisseur: ENZO LIFE SCIENCES
Description: Produced in <i>E. coli</i>. Human LC3-I is fused at the N-terminus to a His-tag.

Image Unavailable-ENZOADIAAP149E

Anti-CASP9 Rabbit Polyclonal Antibody

Référence Produit: (ENZOADIAAP149E)
Fournisseur: ENZO LIFE SCIENCES
Description: The caspases are a family of cysteine proteases that cleave after certain aspartate residues, and are primarily recognized as mediators of apoptosis. caspases are synthesized as inactive zymogens that can be cleaved to form active enzymes following the induction of apoptosis by stress or death receptors. Initiator caspases (e.g. caspase-8 and -10) are activated by dimerization of the zymogen on a dedicated adaptor protein. These activated initiator caspases in-turn cleave downstream effector or executioner caspases (e.g. caspase-3, -6, and -7) in a cascade-like manner, which cleave key cellular proteins that lead to the morphological changes associated with apoptotic cell death.
UOM: 1 * 100 µG
Image Unavailable-ENZOADIAGR530D

Anti-AGRN Mouse Monoclonal Antibody

Fournisseur: ENZO LIFE SCIENCES
Description: Agrin is an essential extracellular matrix component which promotes clustering of nicotinic acetylcholine receptors (nAChRs) and other proteins at the neuromuscular junction during development. Agrin, MuSK, and Rapsyn are all essential components for AChR aggregation, through an unknown mechanism. The C-terminal region of agrin is released into the medium, interacts with receptors on the muscle surface and induces AChR aggregation.

Image Unavailable-ENZOADIAGR540D

Anti-AGRN Mouse Monoclonal Antibody

Fournisseur: ENZO LIFE SCIENCES
Description: Agrin is an essential extracellular matrix component which promotes clustering of nicotinic acetylcholine receptors (nAChRs) and other proteins during development at the neuromuscular junction. Agrin, MuSK and Rapsyn are all essential components for AChR aggregation through an unknown mechanism. The C-terminal region of agrin is released into the medium, interacts with receptors on the muscle surface, and induces AChR aggregation. The central region contains two O-linked glycosylation sites and a domain homologous to domain III of laminin. The N-terminal region anchors agrin to the extracellular matrix via other basal membrane components. This region also contains a protease inhibitor domain and glycosaminoglycan attachment sites, increasing the predicted MW from 200kDa to ~600kDa. The diagram shown indicates the domain structure and functional regions of agrin, as well as domains required for AChR aggregation and alpha-dystroglycan and heparin binding.  Various agrin isoforms are generated by alternative splicing at the X, Y and Z sites, and differ in the presence or absence of small inserts. The isoforms can determine the biological activity of agrin and their expression in specific tissues and stages of development. While no difference in functional activity has been detected between splicing variants at site X, insertion of a 4 aa peptide at site Y modestly increases agrins nAChR clustering activity. Insertion of an 8 aa peptide at splicing site Z increases the clustering activity of soluble rat agrin 10,000 fold.

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Anti-Agrin Mouse Monoclonal Antibody [clone: Agr-33]

Fournisseur: ENZO LIFE SCIENCES
Description: Agrin is an essential extracellular matrix component which promotes clustering of nicotinic acetylcholine receptors (nAChRs) and other proteins at the neuromuscular junction during development.

Image Unavailable-ENZOADIEKS390A

PKA kinase activity kit

Référence Produit: (ENZOADIEKS390A)
Fournisseur: ENZO LIFE SCIENCES
Description: The PKA Kinase activity kit is an efficient assay that utilizes little sample volume. This kit gives you the ability to an end-point or kinetic assay read-out in a convenient 96-well plate based assay and offers easy sample handling protocols. The assay also offers a high signal to background ratio.
UOM: 1 * 1 KIT
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Anti-TOP2A Mouse Monoclonal Antibody [clone: 1C5]

Référence Produit: (ENZOADIKAMCC210E)
Fournisseur: ENZO LIFE SCIENCES
Description: DNA-topoisomerase II, also known as Topo II or Top 2, is a multifunctional nuclear enzyme required during DNA replication, chromosome disjunction at mitosis, and other DNA-related activities because of its ability to alter DNA supercoiling. In mammalian cells, Topo II consists of two isozymes, Topo II-alpha (170kDa) and Topo II-beta (180kDa) and expression and localization of each isoform are distinct and stage specific during the cell cycle. Topo II-beta is expressed constitutively throughout the cell cycle, whereas the expression of Topo II-alpha is cell cycle-regulated, peaking in G2 to M phase and declining to a minimal level at the end of M phase. DNA-topoisomerase II is the target of some of the most active drugs used in chemotherapy and has been shown to have a critical role in neural development.
UOM: 1 * 100 µG
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HSP70 high sensitivity ELISA Kit

Référence Produit: (ENZOADIEKS715)
Fournisseur: ENZO LIFE SCIENCES
Description: Only commercially available kit specifically validated and sensitive enough to quantify HSP70 (HSP72) in serum and plasma samples.
UOM: 1 * 1 KIT
Image Unavailable-ENZOADIEKS725A

HSP70B' ELISA kit

Référence Produit: (ENZOADIEKS725A)
Fournisseur: ENZO LIFE SCIENCES
Description: The HSP70B' EIA kit is a colorimetric immunometric enzyme immunoassay kit with results in < 4.5 hours. Absorbance is read at 450 nm. Save time, money, and precious sample with fully quantitative results and increased sensitivity compared to Western blot analysis.Only commercially available ELISA kit for ultra-sensitive HSP70B' detection in cell lysates, serum, and tissue.
UOM: 1 * 1 KIT
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