Agrin is an essential extracellular matrix component which promotes clustering of nicotinic acetylcholine receptors (nAChRs) and other proteins at the neuromuscular junction during development.
- Dilution range: 10 µg/ml for Immunohistochemistry
Agrin, MuSK, and Rapsyn are all essential components for AChR aggregation, through an unknown mechanism. The C-terminal region of agrin is released into the medium, interacts with receptors on the muscle surface and induces AChR aggregation.
Type: Primary
Antigen: Agrin
Clonality: Monoclonal
Clone: Agr-33
Conjugation:
Epitope: C-Terminal
Host: Mouse
Isotype: IgG1
Reactivity: Mouse, Rat