Votre recherche pour: Chiral+Technologies

Référence Produit: (STMC60074AD)

Fournisseur: STEMCELL Technologies

Description: Rat monoclonal IgM, kappa isotype control antibody, Alexa Fluor® 488-conjugated.

UOM: 1 * 25 µG

*Promo

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Fournisseur: STEMCELL Technologies

Description: Fibroblast growth factor 10 (FGF-10) is a member of the fibroblast growth factor (FGF) family predominantly expressed by mesenchymal fibroblasts during embryonic development (Emoto <i>et al.</i>; Igarashi <i>et al.</i>). It binds with high affinity to fibroblast growth factor receptor 2-IIIb (FGFR2-IIIb), and also has a weaker affinity for FGFR1-IIIb (Beer <i>et al.</i>). FGF-10 and FGF-7 have similar receptor binding properties and target cell specificities but are differentially regulated by components of the extracellular matrix (Emoto <i>et al.</i>; Igarashi <i>et al.</i>). FGF-10 has been shown to mediate epithelial-mesenchymal interactions, which are essential to lung development (Sekine et al; Ware and Matthay). FGF-10 also has a role in mobilisation and proliferation of lung-resident mesenchymal stem cells (MSCs) and protection and repair against acute lung injury (Tong <i>et al.</i>; Ware and Matthay), as well as endodermal differentiation of human pluripotent stem cells to insulin-producing pancreatic-like cells (Takeuchi <i>et al.</i>).

Fournisseur: STEMCELL Technologies

Description: Neurotrophin-4 (NT-4) is a member of the nerve growth factor family which includes neurotrophin-3 (NT-3), brain-derived neurotrophic factor (BDNF), and nerve growth factor (NGF), all of which promote the differentiation, growth, and survival of peripheral and central nervous system neurons (Eide <i>et al.</i>). NT-4 binds and activates tropomyosin receptor kinase B (TrkB) at the cell surface; in doing so, it acts as a survival factor for certain populations of sensory neurons (Berkemeier <i>et al.</i>; Skaper). It has been shown that NT-4, together with BDNF, promotes neurite extension and maturation, as well as maintenance of differentiated cerebellar granule cells (Gao <i>et al.</i>).

Fournisseur: STEMCELL Technologies

Description: Rat monoclonal IgG2b antibody against mouse CD45, FITC-conjugated.

Fournisseur: STEMCELL Technologies

Description: Interleukin 17A (IL-17A) is the founding member of the family of cytokines that includes IL-17B through IL-17F. It is a potent pro-inflammatory cytokine that plays a key role in defense against pathogens. IL-17A and IL-17F signal as homodimers or heterodimers through the same receptor, and activate NF-κB, MAPK, and C/EBP pathways (Gaffen). IL-17A is produced by Th17 cells, CD8+ T cells, γ/δ T cells, natural killer (NK) T cells, B cells, innate lymphoid cells, and mesenchymal stromal cells (MSCs) (Cua and Tato; Gaffen; Mojsilović <i>et al.</i>). IL-17A mediates protection against extracellular pathogens, and together with IL-22 stimulates production of antimicrobial peptides. It induces granulopoiesis factors and neutrophil-specific chemokines. Together with tumor necrosis factor alpha (TNF-α), IL-17A induces a sustained neutrophil recruitment during inflammation (Cua and Tato). IL-17A receptor is expressed at particularly high levels on stromal cells, including MSCs. IL-17A increases the frequency and the average size of fibroblast colony-forming units (CFU-F), as well as the proliferation of marrow-derived MSCs. It enhances osteogenic differentiation, and inhibits adipocyte differentiation and chondrogenesis (Mojsilović <i>et al.</i>).

Fournisseur: STEMCELL Technologies

Description: Mouse monoclonal IgG2a antibody against human, mouse, rat beta-tubulin III, unconjugated.

Fournisseur: STEMCELL Technologies

Description: Mouse monoclonal IgG3, kappa isotype control antibody, PE-conjugated.

Fournisseur: STEMCELL Technologies

Description: Hamster (Armenian) monoclonal IgG1 antibody against mouse CD3e, APC-conjugated.

Fournisseur: STEMCELL Technologies

Description: RANTES (regulated upon activation, normal T cell expressed and secreted), also known as CCL5, is a member of the CC family of chemokines and is able to recruit leukocytes to sites of inflammation (Schall <i>et al.</i>). RANTES is secreted by T lymphocytes, macrophages, platelets, synovial fibroblasts, tubular epithelium, and certain types of tumor cells (Aldinucci and Colombatti; Soria and Ben-Baruch). This chemokine exerts its effect by interacting with the chemokine receptors CCR1, CCR3, CCR4, and CCR5. RANTES plays an active role in recruiting a variety of leukocytes into inflammatory sites, including T cells, macrophages, eosinophils, and basophils. In collaboration with certain cytokines that are released by T cells such as IL-2 and IFN-γ, RANTES also induces the activation and proliferation of NK cells to generate CC chemokine-activated killer cells, which are highly cytolytic (Lv <i>et al.</i>; Maghazachi <i>et al.</i>). It has been shown that RANTES produced by CD8+ T cells inhibits HIV infection of primary human peripheral blood mononuclear cells (Appay and Rowland-Jones; Cocchi <i>et al.</i>).

Fournisseur: STEMCELL Technologies

Description: Nerve growth factor (NGF)-beta is a prototypical member of the neurotrophin family and has a role in the survival and growth of neural cells, regulating cell growth, promoting differentiation into neurons, and neuron migration. The beta subtype of NGF is biologically active in comparison to the alpha-2 and gamma-2 subtypes. NGF-beta in its secreted form can bind to tyrosine kinase A (TrkA) receptor with high affinity and to p75 (NTR) with low affinity (Levi and Alemà; Sofroniew <i>et al.</i>). NGF has been shown to possess pro-inflammatory and pro-fibrogenic properties (Micera <i>et al.</i>). It has also been shown that overexpression of NGF-beta promotes differentiation of bone marrow mesenchymal stem cells into neurons through regulation of AKT and MAPK pathways (Yuan <i>et al.</i>).

Référence Produit: (STMC60018)

Fournisseur: STEMCELL Technologies

Description: Mouse monoclonal IgG1 antibody against human, chimpanzee CD45, unconjugated.

UOM: 1 * 100 µG

*Promo

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Référence Produit: (STMC60004)

Fournisseur: STEMCELL Technologies

Description: Mouse monoclonal IgG2a antibody against human, rhesus, cynomolgus CD14, unconjugated.

UOM: 1 * 100 µG

*Promo

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Fournisseur: STEMCELL Technologies

Description: Animal component-free collagenase for the digestion of native collagen fibrils.

Fournisseur: STEMCELL Technologies

Description: Mouse monoclonal IgG2a antibody against mouse CD45.2, biotin-conjugated.

Fournisseur: STEMCELL Technologies

Description: Rat monoclonal IgG2a antibody against mouse CD4, biotin-conjugated.

Fournisseur: STEMCELL Technologies

Description: Rat monoclonal IgG2a antibody against mouse CD150 (SLAM), unconjugated.