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Image Unavailable-BOSSBS-3755R-A488

Anti-CRKL Rabbit Polyclonal Antibody (Alexa Fluor® 488)

Référence Produit: (BOSSBS-3755R-A488)
Fournisseur: Bioss
Description: Crkl is a 34kDa adaptor protein which has been shown to activate the RAS and JUN kinase signalling pathways and transforms fibroblasts in a RAS dependant manner. Crkl is a substitute of BCR ABL tyrosine kinase. In addition, Crkl has oncogenic potential.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-6874R-A350

Anti-CAT Rabbit Polyclonal Antibody (Alexa Fluor® 350)

Référence Produit: (BOSSBS-6874R-A350)
Fournisseur: Bioss
Description: Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Promotes growth of cells including T-cells, B-cells, myeloid leukemia cells, melanoma cells, mastocytoma cells and normal and transformed fibroblast cells.
UOM: 1 * 100 µl
Image Unavailable-BNC940642-100

Anti-EGFR Mouse Monoclonal Antibody (CF594) [clone: H9B4]

Fournisseur: Biotium
Description: This MAb reacts with a cytoplasmic domain of EGFR. EGFR is a type I receptor tyrosine kinase with sequence homology to erbB-1, -2, -3 -4 or HER-1, -2, -3 -4. It binds to Epidermal Growth Factor (EGF), Transforming Growth Factor-a (TGF-a), Heparin-binding EGF (HB-EGF), amphiregulin, βcellulin & epiregulin.

Image Unavailable-BNC040642-500

Anti-EGFR Mouse Monoclonal Antibody (CF405S) [clone: H9B4]

Fournisseur: Biotium
Description: This MAb reacts with a cytoplasmic domain of EGFR. EGFR is a type I receptor tyrosine kinase with sequence homology to erbB-1, -2, -3 -4 or HER-1, -2, -3 -4. It binds to Epidermal Growth Factor (EGF), Transforming Growth Factor-a (TGF-a), Heparin-binding EGF (HB-EGF), amphiregulin, βcellulin & epiregulin.

Image Unavailable-BOSSBS-0481R-A555

Anti-IFNG Rabbit Polyclonal Antibody (Alexa Fluor® 555)

Référence Produit: (BOSSBS-0481R-A555)
Fournisseur: Bioss
Description: Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-0480R-A488

Anti-IFNG Rabbit Polyclonal Antibody (Alexa Fluor® 488)

Référence Produit: (BOSSBS-0480R-A488)
Fournisseur: Bioss
Description: Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-6817R-CY7

Anti-MAGEA11 Rabbit Polyclonal Antibody (Cy7®)

Référence Produit: (BOSSBS-6817R-CY7)
Fournisseur: Bioss
Description: Acts as androgen receptor coregulator that increases androgen receptor activity by modulating the receptors interdomain interaction. May play a role in embryonal development and tumor transformation or aspects of tumor progression.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-0817R-A680

Anti-MAGE-1 Rabbit Polyclonal Antibody (Alexa Fluor® 680)

Référence Produit: (BOSSBS-0817R-A680)
Fournisseur: Bioss
Description: May be involved in transcriptional regulation through interaction with SNW1 and recruiting histone deactelyase HDAC1. May inhibit notch intracellular domain (NICD) transactivation. May play a role in embryonal development and tumor transformation or aspects of tumor progression. Antigen recognised on a melanoma by autologous cytolytic T-lymphocytes.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-5957R-FITC

Anti-STYK1 Rabbit Polyclonal Antibody (FITC (Fluorescein Isothiocyanate))

Référence Produit: (BOSSBS-5957R-FITC)
Fournisseur: Bioss
Description: Probable tyrosine protein-kinase, which has strong transforming capabilities on a variety of cell lines. When overexpressed, it can also induce tumor cell invasion as well as metastasis in distant organs. May act by activating both MAP kinase and phosphatidylinositol 3'-kinases (PI3K) pathways (By similarity).
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-2969R-A750

Anti-HPV33 E7 Rabbit Polyclonal Antibody (Alexa Fluor® 750)

Référence Produit: (BOSSBS-2969R-A750)
Fournisseur: Bioss
Description: E7 protein has both transforming and trans-activating activities. Disrupts the function of host retinoblastoma protein RB1/pRb, which is a key regulator of the cell cycle. Induces the disassembly of the E2F1 transcription factors from RB1, with subsequent transcriptional activation of E2F1-regulated S-phase genes. Inactivation of the ability of RB1 to arrest the cell cycle is critical for cellular transformation, uncontrolled cellular growth and proliferation induced by viral infection. Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery to achieve viral genome replication. Interferes with histone deacetylation mediated by HDAC1 and HDAC2, leading to activation of transcription (By similarity).
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-1910R-CY7

Anti-TGFBR3 Rabbit Polyclonal Antibody (Cy7®)

Référence Produit: (BOSSBS-1910R-CY7)
Fournisseur: Bioss
Description: Membrane Receptors Transforming growth factor beta is a multifunctional cytokine known to modulate several tissue development and repair processes, including cell differentiation, cell cycle progression, cellular migration, adhesion, and extracellular matrix production. There are 3 forms encoded by separate genes TGFB1, TGFB2, and TGFB3. The diverse effects of TGF beta are mediated by the TGF beta receptors and cell surface binding proteins. In addition to type I TGF beta receptor (TGFBR1) and type II (TFGBR2), type III (TGF beta III receptor) has been identified. It is a glycoprotein that binds TGF beta and exists in both a membrane bound and a soluble form. It may serve as a receptor accessory molecule in both the TGF beta and fibroblast growth factor systems. TGF beta III receptor lacks a recognizable signaling domain and has no clearly defined role in TGF beta signaling. Endothelial cells undergoing epithelial mesenchymal transformation express TGF beta III receptor, and TGF beta III receptor specific antisera inhibits mesenchyme formation and migration. Misexpression of TGF beta III receptor in nontransforming ventricular endothelial cells conferrs transformation in response to TGFB2. These results support a model where TGF beta III receptor localizes transformation in the heart and plays an essential, nonredundant role in TGF beta signaling. TGF beta III receptor, or beta glycan, can function as an inhibin coreceptor with ActRII. TGF beta III receptor binds inhibin with high affinity and enhances binding in cells coexpressing ActRII and TGF beta III receptor. Inhibin forms crosslinked complexes with both recombinant and endogenously expressed TGF beta III receptor and ActRII. TGF beta III receptor confers inhibin sensitivity to cell lines that otherwise respond poorly to this hormone.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-6165R-FITC

Anti-HRAS Rabbit Polyclonal Antibody (FITC (Fluorescein Isothiocyanate))

Référence Produit: (BOSSBS-6165R-FITC)
Fournisseur: Bioss
Description: The KRAS gene encodes the human cellular homolog of a transforming gene isolated from the Kirsten rat sarcoma virus. The RAS proteins are GDP/GTP-binding proteins that act as intracellular signal transducers. The most well-studied members of the RAS (derived from 'RAt Sarcoma' virus) gene family include KRAS, HRAS, and NRAS. These genes encode immunologically related proteins with a molecular mass of 21 kD and are homologs of rodent sarcoma virus genes that have transforming abilities. While these wildtype cellular proteins in humans play a vital role in normal tissue signaling, including proliferation, differentiation, and senescence, mutated genes are potent oncogenes that play a role in many human cancers.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-6165R-A750

Anti-HRAS+KRAS Rabbit Polyclonal Antibody (Alexa Fluor® 750)

Référence Produit: (BOSSBS-6165R-A750)
Fournisseur: Bioss
Description: The KRAS gene encodes the human cellular homolog of a transforming gene isolated from the Kirsten rat sarcoma virus. The RAS proteins are GDP/GTP-binding proteins that act as intracellular signal transducers. The most well-studied members of the RAS (derived from 'RAt Sarcoma' virus) gene family include KRAS, HRAS, and NRAS. These genes encode immunologically related proteins with a molecular mass of 21 kD and are homologs of rodent sarcoma virus genes that have transforming abilities. While these wildtype cellular proteins in humans play a vital role in normal tissue signaling, including proliferation, differentiation, and senescence, mutated genes are potent oncogenes that play a role in many human cancers.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-4778R-A647

Anti-TNFRSF8 Rabbit Polyclonal Antibody (Alexa Fluor® 647)

Référence Produit: (BOSSBS-4778R-A647)
Fournisseur: Bioss
Description: Receptor for TNFSF8/CD30L. May play a role in the regulation of cellular growth and transformation of activated lymphoblasts. Regulates gene expression through activation of NF-kappa-B (By similarity).
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-6817R-A750

Anti-MAGEA11 Rabbit Polyclonal Antibody (Alexa Fluor® 750)

Référence Produit: (BOSSBS-6817R-A750)
Fournisseur: Bioss
Description: Acts as androgen receptor coregulator that increases androgen receptor activity by modulating the receptors interdomain interaction. May play a role in embryonal development and tumor transformation or aspects of tumor progression.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-6817R-A647

Anti-MAGEA11 Rabbit Polyclonal Antibody (Alexa Fluor® 647)

Référence Produit: (BOSSBS-6817R-A647)
Fournisseur: Bioss
Description: Acts as androgen receptor coregulator that increases androgen receptor activity by modulating the receptors interdomain interaction. May play a role in embryonal development and tumor transformation or aspects of tumor progression.
UOM: 1 * 100 µl
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