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Image Unavailable-BOSSBS-6043R-CY5.5

Anti-NBL1 Rabbit Polyclonal Antibody (Cy5.5®)

Référence Produit: (BOSSBS-6043R-CY5.5)
Fournisseur: Bioss
Description: NBL1 (Neuroblastoma, suppression of tumorigenicity 1) is a candidate tumor suppressor of neuroblastoma and may play a role in preventing cells from entering the final stage (G1/S) of the transformation process. NBL1 is a member of the evolutionarily conserved CAN (Cerberus and DAN) family of proteins, which contain a domain resembling the CTCK (C-terminal cystine knot-like) motif found in a number of signaling molecules. It is a member of a class of glycoproteins shown to be secreted inhibitors of the transforming growth factor-beta (TGF-beta) and bone morphogenic protein pathways.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-3846R-FITC

Anti-TGFB5/ TGFB1 Rabbit Polyclonal Antibody (FITC (Fluorescein Isothiocyanate))

Référence Produit: (BOSSBS-3846R-FITC)
Fournisseur: Bioss
Description: Transforming Growth Factor beta 5 (TGF beta 5) is a member of the TGF beta family of growth factors. The TGF beta polypeptides are multifunctional; capable of influencing cell proliferation, differentiation, and other functions in a wide range of cell types. Transformed, as well as nonneoplastic tissues, release transforming growth factors; and essentially all mammalian cells possess a specific TGF receptor. The multi-modal nature of TGF beta is seen in its ability to stimulate or inhibit cellular proliferation. In general, cells of mesenchymal origin appear to be stimulated by TGF beta whereas cells of epithelial or neuroectodermal origin are inhibited by the peptide.
UOM: 1 * 100 µl
Image Unavailable-ENZOALX8049070100

Anti-TNF-related Apoptosis-inducing Ligand Mouse Monoclonal Antibody [clone: RIK-2]

Référence Produit: (ENZOALX8049070100)
Fournisseur: ENZO LIFE SCIENCES
Description: Induces apoptosis in tumorigenic and transformed cell lines, involved in T cell mediated cytotoxicity, TRAIL ligand of cognate receptors induces NF-kappa-B signaling in a variety of cell types. TRAIL is a 30kDa protein known as TNF-related apoptosis inducing ligand, CD253, TNFSF10, or Apo-2L. It can be expressed as a cell surface (30kDa) and soluble ligand (19-20kDa) produced by megakaryocytes and platelets, monocytes, neutrophils, NK cells and activated T cells. This antigen is also expressed on tumor cells and transformed cell lines. TRAIL has been reported to induce apoptosis in tumor and transformed cell lines by a caspase-dependent process. This antibody is useful for flow cytometric staining and blocking studies.
UOM: 1 * 100 µG
Image Unavailable-BOSSBS-2763R

Anti-CRK Rabbit Polyclonal Antibody

Référence Produit: (BOSSBS-2763R)
Fournisseur: Bioss
Description: Crk p38 (CrkII) is an isoform of the protein Crk. CrkI and CrkII are produced from the same crk gene by alternative splicing. The two isoforms differ in their biological activities with CrkII having less transforming activity than CrkI.Crk p38 is a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. It has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Crk is believed to be a regulator of invasive responses because increased levels of the protein have been observed in multiple human cancers. In vivo studies have demonstrated that decreased levels of Crk remarkably inhibits tumor formation and its invasive growth.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-2763R-A750

Anti-Crk p38 Rabbit Polyclonal Antibody (Alexa Fluor® 750)

Référence Produit: (BOSSBS-2763R-A750)
Fournisseur: Bioss
Description: Crk p38 (CrkII) is an isoform of the protein Crk. CrkI and CrkII are produced from the same crk gene by alternative splicing. The two isoforms differ in their biological activities with CrkII having less transforming activity than CrkI.Crk p38 is a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. It has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Crk is believed to be a regulator of invasive responses because increased levels of the protein have been observed in multiple human cancers. In vivo studies have demonstrated that decreased levels of Crk remarkably inhibits tumor formation and its invasive growth.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-6043R-HRP

Anti-NBL1 Rabbit Polyclonal Antibody (HRP (Horseradish Peroxidase))

Référence Produit: (BOSSBS-6043R-HRP)
Fournisseur: Bioss
Description: NBL1 (Neuroblastoma, suppression of tumorigenicity 1) is a candidate tumor suppressor of neuroblastoma and may play a role in preventing cells from entering the final stage (G1/S) of the transformation process. NBL1 is a member of the evolutionarily conserved CAN (Cerberus and DAN) family of proteins, which contain a domain resembling the CTCK (C-terminal cystine knot-like) motif found in a number of signaling molecules. It is a member of a class of glycoproteins shown to be secreted inhibitors of the transforming growth factor-beta (TGF-beta) and bone morphogenic protein pathways.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-6043R-A647

Anti-NBL1 Rabbit Polyclonal Antibody (Alexa Fluor® 647)

Référence Produit: (BOSSBS-6043R-A647)
Fournisseur: Bioss
Description: NBL1 (Neuroblastoma, suppression of tumorigenicity 1) is a candidate tumor suppressor of neuroblastoma and may play a role in preventing cells from entering the final stage (G1/S) of the transformation process. NBL1 is a member of the evolutionarily conserved CAN (Cerberus and DAN) family of proteins, which contain a domain resembling the CTCK (C-terminal cystine knot-like) motif found in a number of signaling molecules. It is a member of a class of glycoproteins shown to be secreted inhibitors of the transforming growth factor-beta (TGF-beta) and bone morphogenic protein pathways.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-6136R-CY5

Anti-AdV 5 E1A Rabbit Polyclonal Antibody (Cy5®)

Référence Produit: (BOSSBS-6136R-CY5)
Fournisseur: Bioss
Description: The early region (E1) of the adenovirus genome, responsible for transforming activity, is localized within the left most 11% of the viral genome and consists of two transcriptional units E1A and E1B. E1A is sufficient for partial transformation and immortalization of primary cells. E1A gene products are necessary for normal levels of transcription of the other early regions of the adenovirus genome during productive infection and are able to either activate or repress the transcription of specific cellular genes. E1A forms specific complexes with cellular proteins including p105 causing inhibition of the cell cycle inducing arresting function of p105.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-3846R-A488

Anti-TGFB5/ TGFB1 Rabbit Polyclonal Antibody (Alexa Fluor® 488)

Référence Produit: (BOSSBS-3846R-A488)
Fournisseur: Bioss
Description: Transforming Growth Factor beta 5 (TGF beta 5) is a member of the TGF beta family of growth factors. The TGF beta polypeptides are multifunctional; capable of influencing cell proliferation, differentiation, and other functions in a wide range of cell types. Transformed, as well as nonneoplastic tissues, release transforming growth factors; and essentially all mammalian cells possess a specific TGF receptor. The multi-modal nature of TGF beta is seen in its ability to stimulate or inhibit cellular proliferation. In general, cells of mesenchymal origin appear to be stimulated by TGF beta whereas cells of epithelial or neuroectodermal origin are inhibited by the peptide.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-3846R-A350

Anti-TGFB5/ TGFB1 Rabbit Polyclonal Antibody (Alexa Fluor® 350)

Référence Produit: (BOSSBS-3846R-A350)
Fournisseur: Bioss
Description: Transforming Growth Factor beta 5 (TGF beta 5) is a member of the TGF beta family of growth factors. The TGF beta polypeptides are multifunctional; capable of influencing cell proliferation, differentiation, and other functions in a wide range of cell types. Transformed, as well as nonneoplastic tissues, release transforming growth factors; and essentially all mammalian cells possess a specific TGF receptor. The multi-modal nature of TGF beta is seen in its ability to stimulate or inhibit cellular proliferation. In general, cells of mesenchymal origin appear to be stimulated by TGF beta whereas cells of epithelial or neuroectodermal origin are inhibited by the peptide.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-6043R-CY5

Anti-NBL1 Rabbit Polyclonal Antibody (Cy5®)

Référence Produit: (BOSSBS-6043R-CY5)
Fournisseur: Bioss
Description: NBL1 (Neuroblastoma, suppression of tumorigenicity 1) is a candidate tumor suppressor of neuroblastoma and may play a role in preventing cells from entering the final stage (G1/S) of the transformation process. NBL1 is a member of the evolutionarily conserved CAN (Cerberus and DAN) family of proteins, which contain a domain resembling the CTCK (C-terminal cystine knot-like) motif found in a number of signaling molecules. It is a member of a class of glycoproteins shown to be secreted inhibitors of the transforming growth factor-beta (TGF-beta) and bone morphogenic protein pathways.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-6385R-A680

Anti-Gas1 Rabbit Polyclonal Antibody (Alexa Fluor® 680)

Référence Produit: (BOSSBS-6385R-A680)
Fournisseur: Bioss
Description: Specific growth arrest protein involved in growth suppression. Blocks entry to S phase. Prevents cycling of normal and transformed cells.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-1719R-A647

Anti-HPV16 E6 + HPV18 E6 Rabbit Polyclonal Antibody (Alexa Fluor® 647)

Référence Produit: (BOSSBS-1719R-A647)
Fournisseur: Bioss
Description: Transcriptional transactivator. Binds double-stranded DNA (By similarity). Has transforming activity. Inactivates, with E6-AP ubiquitin-protein ligase, the human p53/TP53 tumor suppressor protein by targeting it to degradation. Binds and targets human MUPP1/MPDZ protein to degradation. Those two functions presumably contribute to transforming activity. Interaction with human FBLN1 protein also seems to be linked to cell transformation.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-6385R-FITC

Anti-GAS1 Rabbit Polyclonal Antibody (FITC (Fluorescein Isothiocyanate))

Référence Produit: (BOSSBS-6385R-FITC)
Fournisseur: Bioss
Description: Specific growth arrest protein involved in growth suppression. Blocks entry to S phase. Prevents cycling of normal and transformed cells.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-6385R-A350

Anti-GAS1 Rabbit Polyclonal Antibody (Alexa Fluor® 350)

Référence Produit: (BOSSBS-6385R-A350)
Fournisseur: Bioss
Description: Specific growth arrest protein involved in growth suppression. Blocks entry to S phase. Prevents cycling of normal and transformed cells.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-2763R-A647

Anti-CRK Rabbit Polyclonal Antibody (Alexa Fluor® 647)

Référence Produit: (BOSSBS-2763R-A647)
Fournisseur: Bioss
Description: Crk p38 (CrkII) is an isoform of the protein Crk. CrkI and CrkII are produced from the same crk gene by alternative splicing. The two isoforms differ in their biological activities with CrkII having less transforming activity than CrkI.Crk p38 is a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. It has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Crk is believed to be a regulator of invasive responses because increased levels of the protein have been observed in multiple human cancers. In vivo studies have demonstrated that decreased levels of Crk remarkably inhibits tumor formation and its invasive growth.
UOM: 1 * 100 µl
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