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Image Unavailable-BOSSBS-6817R-CY3

Anti-MAGEA11 Rabbit Polyclonal Antibody (Cy3®)

Référence Produit: (BOSSBS-6817R-CY3)
Fournisseur: Bioss
Description: Acts as androgen receptor coregulator that increases androgen receptor activity by modulating the receptors interdomain interaction. May play a role in embryonal development and tumor transformation or aspects of tumor progression.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-2495R-A350

Anti-TNFRSF8 Rabbit Polyclonal Antibody (Alexa Fluor® 350)

Référence Produit: (BOSSBS-2495R-A350)
Fournisseur: Bioss
Description: Receptor for TNFSF8/CD3L. May play a role in the regulation of cellular growth and transformation of activated lymphoblasts. Regulates gene expression through activation of NF-kappa-B.
UOM: 1 * 100 µl
Product Image-BOSSBS-6385R

Anti-Gas1 Rabbit Polyclonal Antibody

Référence Produit: (BOSSBS-6385R)
Fournisseur: Bioss
Description: Specific growth arrest protein involved in growth suppression. Blocks entry to S phase. Prevents cycling of normal and transformed cells.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-4778R-A555

Anti-TNFRSF8 Rabbit Polyclonal Antibody (Alexa Fluor® 555)

Référence Produit: (BOSSBS-4778R-A555)
Fournisseur: Bioss
Description: Receptor for TNFSF8/CD30L. May play a role in the regulation of cellular growth and transformation of activated lymphoblasts. Regulates gene expression through activation of NF-kappa-B (By similarity).
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-4778R-FITC

Anti-TNFRSF8 Rabbit Polyclonal Antibody (FITC (Fluorescein Isothiocyanate))

Référence Produit: (BOSSBS-4778R-FITC)
Fournisseur: Bioss
Description: Receptor for TNFSF8/CD30L. May play a role in the regulation of cellular growth and transformation of activated lymphoblasts. Regulates gene expression through activation of NF-kappa-B (By similarity).
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-2763R-FITC

Anti-CRK Rabbit Polyclonal Antibody (FITC (Fluorescein Isothiocyanate))

Référence Produit: (BOSSBS-2763R-FITC)
Fournisseur: Bioss
Description: Crk p38 (CrkII) is an isoform of the protein Crk. CrkI and CrkII are produced from the same crk gene by alternative splicing. The two isoforms differ in their biological activities with CrkII having less transforming activity than CrkI.Crk p38 is a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. It has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Crk is believed to be a regulator of invasive responses because increased levels of the protein have been observed in multiple human cancers. In vivo studies have demonstrated that decreased levels of Crk remarkably inhibits tumor formation and its invasive growth.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-2763R-A555

Anti-CRK Rabbit Polyclonal Antibody (Alexa Fluor® 555)

Référence Produit: (BOSSBS-2763R-A555)
Fournisseur: Bioss
Description: Crk p38 (CrkII) is an isoform of the protein Crk. CrkI and CrkII are produced from the same crk gene by alternative splicing. The two isoforms differ in their biological activities with CrkII having less transforming activity than CrkI.Crk p38 is a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. It has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Crk is believed to be a regulator of invasive responses because increased levels of the protein have been observed in multiple human cancers. In vivo studies have demonstrated that decreased levels of Crk remarkably inhibits tumor formation and its invasive growth.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-6817R-FITC

Anti-MAGEA11 Rabbit Polyclonal Antibody (FITC (Fluorescein Isothiocyanate))

Référence Produit: (BOSSBS-6817R-FITC)
Fournisseur: Bioss
Description: Acts as androgen receptor coregulator that increases androgen receptor activity by modulating the receptors interdomain interaction. May play a role in embryonal development and tumor transformation or aspects of tumor progression.
UOM: 1 * 100 µl
Image Unavailable-ENZOBMLG2280001

α-Hydroxyfarnesylphosphonic acid (synthétique) ≥98% (par CCM)

Référence Produit: (ENZOBMLG2280001)
Fournisseur: ENZO LIFE SCIENCES
Description: Potent inhibitor of farnesyltransferase in isolated enzyme assays (IC50=30 nM) and in whole cells. Inhibition of farnesyltransferase is selective over geranylgeranyltransferase I and II (IC50=35.8 µM and 67 µM respectively). α-Hydroxyfarnesylphosphonic acid inhibited (1 µM) Ras processing in Ha-ras-transformed NIH 3T3 fibroblasts.
UOM: 1 * 1 mg
Image Unavailable-ENZOADISPA725D

Anti-ERP57 Mouse Monoclonal Antibody

Fournisseur: ENZO LIFE SCIENCES
Description: ERp57 (also known as Grp58), a member of the Thioredoxin superfamily, is an ER protein with disulfide isomerase activity. It has been shown to increase after oncogenic transformation and to be a component of the MHC Class I peptide-loading complex.

Image Unavailable-BOSSBS-4736R-CY3

Anti-HMMR Rabbit Polyclonal Antibody (Cy3®)

Référence Produit: (BOSSBS-4736R-CY3)
Fournisseur: Bioss
Description: Involved in cell motility. When hyaluronan binds to HMMR, the phosphorylation of a number of proteins, including PTK2/FAK1 occurs. May also be involved in cellular transformation and metastasis formation, and in regulating extracellular-regulated kinase (ERK) activity.
UOM: 1 * 100 µl
Product Image-BSENC-1541-100

Anti-TGF-1 Chicken Polyclonal Antibody

Référence Produit: (BSENC-1541-100)
Fournisseur: Biosensis
Description: Transforming growth factor beta-1 (TGFB1) is a multi-functional cytokine with roles in proliferation, differentiation and other functions in many cell types. The secreted TGFB1 protein is cleaved into a latency-associated peptide (LAP) and a mature TGFB1 peptide (Ref: SWISS-Prot).
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-1910R-CY7

Anti-TGFBR3 Rabbit Polyclonal Antibody (Cy7®)

Référence Produit: (BOSSBS-1910R-CY7)
Fournisseur: Bioss
Description: Membrane Receptors Transforming growth factor beta is a multifunctional cytokine known to modulate several tissue development and repair processes, including cell differentiation, cell cycle progression, cellular migration, adhesion, and extracellular matrix production. There are 3 forms encoded by separate genes TGFB1, TGFB2, and TGFB3. The diverse effects of TGF beta are mediated by the TGF beta receptors and cell surface binding proteins. In addition to type I TGF beta receptor (TGFBR1) and type II (TFGBR2), type III (TGF beta III receptor) has been identified. It is a glycoprotein that binds TGF beta and exists in both a membrane bound and a soluble form. It may serve as a receptor accessory molecule in both the TGF beta and fibroblast growth factor systems. TGF beta III receptor lacks a recognizable signaling domain and has no clearly defined role in TGF beta signaling. Endothelial cells undergoing epithelial mesenchymal transformation express TGF beta III receptor, and TGF beta III receptor specific antisera inhibits mesenchyme formation and migration. Misexpression of TGF beta III receptor in nontransforming ventricular endothelial cells conferrs transformation in response to TGFB2. These results support a model where TGF beta III receptor localizes transformation in the heart and plays an essential, nonredundant role in TGF beta signaling. TGF beta III receptor, or beta glycan, can function as an inhibin coreceptor with ActRII. TGF beta III receptor binds inhibin with high affinity and enhances binding in cells coexpressing ActRII and TGF beta III receptor. Inhibin forms crosslinked complexes with both recombinant and endogenously expressed TGF beta III receptor and ActRII. TGF beta III receptor confers inhibin sensitivity to cell lines that otherwise respond poorly to this hormone.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-13146R

Anti-TRRAP Rabbit Polyclonal Antibody

Référence Produit: (BOSSBS-13146R)
Fournisseur: Bioss
Description: The transcription factors c-Myc and E2F are involved in regulating cell cycle progression. Overexpression of c-Myc in certain cell types induces noncycling cells to enter the cell cycle via a mechanism involving E2F-1 (1). E2F-1 is thought to regulate c-Myc expression via interactions with the retinoblastoma protein (2). TRRAP (for transformation/transcription domain-associated protein) interacts specifically with both c-Myc and E2F-1. Expression of trans-activated mutant TRRAP inhibits the oncogenic transformation of both c-Myc and E2F-1, suggesting that TRRAP is required for these oncogenic transcription factor pathways (3). TRRAP shares homology with the ATM/PI 3-kinase family, and it is highly conserved in evolution (4,5).
UOM: 1 * 100 µl
Product Image-392-0420

VWR®, Cell culture media, McCoy's 5A medium

Référence Produit: (392-0420)
Fournisseur: VWR Chemicals
Description: McCoy’s media were originally formulated for growth and support of lymphocytes. This final modification produced a medium identical to RPMI 1629. McCoy's 5A media supports the indefinite proliferation of Walker 256 carcinoma cells. In addition, it is excellent for the propagation of leukocytes, biopsy tissues, a broad range of human and rat normal or transformed cell types, the most current primary and continuous cell lines.
UOM: 1 * 500 mL

FDS (Fiche de données de sécurité) Certificats.


Image Unavailable-BOSSBS-13115R-A680

Anti-ETV6/Tel Rabbit Polyclonal Antibody (Alexa Fluor® 680)

Référence Produit: (BOSSBS-13115R-A680)
Fournisseur: Bioss
Description: Transcriptional repressor; binds to the DNA sequence 5'-CCGGAAGT-3'. Plays a role in hematopoiesis and malignant transformation.
UOM: 1 * 100 µl
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