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Image Unavailable-BOSSBS-12397R-A647

Anti-MAML2 Rabbit Polyclonal Antibody (Alexa Fluor® 647)

Référence Produit: (BOSSBS-12397R-A647)
Fournisseur: Bioss
Description: Notch receptors are involved in cell-fate determination in organisms as diverse as flies, frogs, and humans (1). The 'mastermind' gene has been identified in multiple genetic screens for modifiers of Notch mutations in Drosophila melanogaster (2). In Drosophila, loss-of-function mutations of Notch produce a 'neurogenic' phenotype in which cells destined to become epidermis switch fate and differentiate to neural cells (2). The human homolog, mastermind-like 1 (Mam1), localizes to nuclear bodies (2-4). Mam1 binds to the ankyrin repeat domain of all four mammalian Notch receptors, forms a DNA-binding complex with ICN and RBP-Jk, and amplifies Notch-induced transcription of Hes1 (2). Mam1 is an essential component of the transcriptional apparatus of Notch signaling (5). The gene which encodes Mam1 maps to human chromosome 5 (4).
UOM: 1 * 100 µl
Product Image-HUBE6152

Accessories for Huber thermostats and baths

Référence Produit: (HUBE6152)
Fournisseur: HUBER
Description: Float switch, Pour: Leak monitoring
UOM: 1 * 1 Pce
Product Image-521-4188

High performance centrifuges, Avanti™ JXN-26

Fournisseur: Beckman Coulter
Description: Experience simplified high-throughput sample processing and more control with the JXN-26 centrifuge with powerful high speed features, low heat output, imbalance tolerance and quiet performance. The JXN-26 has a maximum capacity of 6,0 L and 2,6×10⁴ min⁻¹ (82000×g). The Friction Reduction System (FRS) means the JNX-26 runs quicker, quieter and cooler, with shorter cycle times with high-torque because of the exclusive Switched Reluctance (SR) drive. Stores up-to 1000 user-defined programs.

Product Image-LBCP3961622

Powder filtered systems, XPert™

Référence Produit: (LBCP3961622)
Fournisseur: LABCONCO
Description: XPert™ Bulk Powder Filtered System is designed to provide user protection from hazardous airborne particulates and fumes generated during powder transfer operations. Patented features include an ergonomic air foil with Clean-Sweep openings to enhance airflow and a zone-perforated rear baffle that creates horizontal laminar airflow to maximize containment. The system includes a built-in blower, 99,99% efficient HEPA filter, true bag-in/bag-out filter disposal system, and pre-wired fluorescent light and switches for blower and light.
UOM: 1 * 1 Pce
Image Unavailable-BOSSBS-4002R-A488

Anti-PRKAA1 Rabbit Polyclonal Antibody (Alexa Fluor® 488)

Référence Produit: (BOSSBS-4002R-A488)
Fournisseur: Bioss
Description: The protein encoded by this gene belongs to the ser/thr protein kinase family. It is the catalytic subunit of the 5'-prime-AMP-activated protein kinase (AMPK). AMPK is a cellular energy sensor conserved in all eukaryotic cells. The kinase activity of AMPK is activated by the stimuli that increase the cellular AMP/ATP ratio. AMPK regulates the activities of a number of key metabolic enzymes through phosphorylation. It protects cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq].
UOM: 1 * 100 µl
Product Image-BOSSBS-12220R

Anti-ZNF423 Rabbit Polyclonal Antibody

Référence Produit: (BOSSBS-12220R)
Fournisseur: Bioss
Description: Transcription factor that can both act as an activator or a repressor depending on the context. Plays a central role in BMP signaling and olfactory neurogenesis. Associates with SMADs in response to BMP2 leading to activate transcription of BMP target genes. Acts as a transcriptional repressor via its interaction with EBF1, a transcription factor involved in terminal olfactory receptor neurons differentiation; this interaction preventing EBF1 to bind DNA and activate olfactory-specific genes. Involved in olfactory neurogenesis by participating in a developmental switch that regulates the transition from differentiation to maturation in olfactory receptor neurons. Controls proliferation and differentiation of neural precursors in cerebellar vermis formation.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-10466R-A647

Anti-RHOG Rabbit Polyclonal Antibody (Alexa Fluor® 647)

Référence Produit: (BOSSBS-10466R-A647)
Fournisseur: Bioss
Description: This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. The encoded protein facilitates translocation of a functional guanine nucleotide exchange factor (GEF) complex from the cytoplasm to the plasma membrane where ras-related C3 botulinum toxin substrate 1 is activated to promote lamellipodium formation and cell migration. Two related pseudogene have been identified on chromosomes 20 and X. [provided by RefSeq, Aug 2011].
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-3967R-FITC

Anti-AMPK beta 1 + 2 Rabbit Polyclonal Antibody (FITC (Fluorescein Isothiocyanate))

Référence Produit: (BOSSBS-3967R-FITC)
Fournisseur: Bioss
Description: PRKAB2 ans PRKAB1 are regulatory subunits of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status and plays a role in protecting cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways. AMPK is responsible for the regulation of fatty acid synthesis by phosphorylation of acetyl-CoA carboxylase (ACC). It also regulates cholesterol synthesis via phosphorylation and inactivation of hydroxymethylglutaryl-CoA reductase (HMGCR) and hormone-sensitive lipase. PRKAB2 may be a positive regulator of AMPK activity.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-6163R-CY5

Anti-DIRAS1 Rabbit Polyclonal Antibody (Cy5®)

Référence Produit: (BOSSBS-6163R-CY5)
Fournisseur: Bioss
Description: The three human RAS genes encode highly related 188 to 189 amino acid proteins, designated H-Ras, N-Ras and K-Ras4A and K-Ras4B (the two K-Ras proteins arise from alternative gene splicing). Ras proteins function as binary molecular switches that control intracellular signaling networks. Ras-regulated signal pathways control such processes as actin cytoskeletal integrity, proliferation, differentiation, cell adhesion, apoptosis, and cell migration. Ras and ras-related proteins are often deregulated in cancers, leading to increased invasion and metastasis, and decreased apoptosis.DIRAS1 displays low GTPase activity and exists predominantly in the GTP-bound form. It is highly expressed in heart and brain.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-6163R-CY5.5

Anti-DIRAS1 Rabbit Polyclonal Antibody (Cy5.5®)

Référence Produit: (BOSSBS-6163R-CY5.5)
Fournisseur: Bioss
Description: The three human RAS genes encode highly related 188 to 189 amino acid proteins, designated H-Ras, N-Ras and K-Ras4A and K-Ras4B (the two K-Ras proteins arise from alternative gene splicing). Ras proteins function as binary molecular switches that control intracellular signaling networks. Ras-regulated signal pathways control such processes as actin cytoskeletal integrity, proliferation, differentiation, cell adhesion, apoptosis, and cell migration. Ras and ras-related proteins are often deregulated in cancers, leading to increased invasion and metastasis, and decreased apoptosis.DIRAS1 displays low GTPase activity and exists predominantly in the GTP-bound form. It is highly expressed in heart and brain.
UOM: 1 * 100 µl
Product Image-PRSI36-148

Anti-CD40 Rat Monoclonal Antibody [clone: FGK45]

Référence Produit: (PRSI36-148)
Fournisseur: ProSci Inc.
Description: CD40 belongs to the TNF-receptor superfamily and is essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. The interaction of CD40-CD40L is necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. CD40 is constitutively expressed by antigen presenting cells, including dendritic cells, B cells and macrophages. Consistent with its widespread expression on normal cells, CD40 is also expressed on a wide range of tumor cells, including non-Hodgkin's and Hodgkin's lymphomas, myeloma and some carcinomas including nasopharynx, bladder, cervix, kidney and ovary.
UOM: 1 * 100 µG
Product Image-70-7041-U500

Anti-IL4 Rat Monoclonal Antibody [clone: 11B11]

Fournisseur: Tonbo Biosciences
Description: The 11B11 antibody binds to mouse Interleukin-4 (IL-4), a 14 kDa cytokine that is largely secreted by activated T cells of the Th2 subset, and to some degree by NKT and mast cells. This cytokine acts as a stimulatory factor for B cells, inducing their proliferation and differentiation, as well as playing a role in immunoglobulin class-switching. IL-4 may also provide autocrine stimulation for T cells, and affect the function of antigen presenting cells such as macrophages and dendritic cells. IL-4 can bind and signal via three cell surface receptor types: CD124 by itself, CD124 in combination with the common gamma chain (type I complex), or CD124 combined with CD213a1 (type II complex).

Product Image-554-2647

Vannes de commutation manuelles 2 et 6 positions, Rheodyne®

Fournisseur: IDEX RHEODYNE
Description: Rheodyne®, Vanne de commutation 7 ports, 6 positions 7060, 6 voies, ports 10-32 pour les tubes de 1/16 de diamètre externe, Ø de passage du stator de 0,4 mm, Acier inoxydable

Product Image-554-2669

Vannes haute pression MXP, Rheodyne®, MX Series II™

Fournisseur: IDEX RHEODYNE
Description: Ces vannes actionnées à haute pression sont conçues pour être ajoutées à un instrument existant ou pour fonctionner de manière optimale avec des configurations de laboratoire autonomes.

Product Image-WHEAI050694

'Accessories for peristaltic pumps, Omnispense® Plus, Wheat

Référence Produit: (WHEAI050694)
Fournisseur: DWK Life Sciences
Description: Foot switch, Pour: Peristaltic pumps Omnispense® Plus and Unispense® µP
UOM: 1 * 1 Pce
Image Unavailable-BOSSBS-4002R-A680

Anti-AMPK alpha-1/2 Thr183/Thr172 Rabbit Polyclonal Antibody (Alexa Fluor® 680)

Référence Produit: (BOSSBS-4002R-A680)
Fournisseur: Bioss
Description: The protein encoded by this gene belongs to the ser/thr protein kinase family. It is the catalytic subunit of the 5'-prime-AMP-activated protein kinase (AMPK). AMPK is a cellular energy sensor conserved in all eukaryotic cells. The kinase activity of AMPK is activated by the stimuli that increase the cellular AMP/ATP ratio. AMPK regulates the activities of a number of key metabolic enzymes through phosphorylation. It protects cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
UOM: 1 * 100 µl
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