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Streptozocine 97 (~75% α-anomer basis), powder_off-white

Marques : MP Biomedicals
Ratings: Ecrire un avis

Total Evaluation: 0
Moyenne des Notes : 0.0 sur 5

Danger

Synonyme(s): 1-Methyl-1-nitroso-3-((2S,3R,4R,5S,6R)-2,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-3-yl)urea, Streptozotocin

02100557.1 02100557.5 0210055701 0210055705
ICNA02100557.1EA 76.7 EUR
ICNA02100557.1 ICNA02100557.5 ICNA0210055701 ICNA0210055705
Streptozocine 97 (~75% α-anomer basis), powder_off-white
Streptozocine

Streptozotocin, a glucosamine-nitrosourea, is a DNA alkylating agent that enters cells exclusively via the GLUT2 glucose transport protein. Streptozocin, a diabetagen, is especially toxic to pancreatic islet insulin-producing β-cells. It is toxic to GLUT2 positive neuroendocrine tumor cells.


  • Extinction Coefficient (E1%): EmM(228 nm): 6.36 (ethanol)
  • Biological half-life in cell culture medium was shown to be approximately 19 minutes.


Streptozocin is used to induce Type 1 diabetes for medical research. It has been used for the treatment of malignant insulinoma It is used mainly in the treatment of pancreatic (islet-cell) tumors.


An N-nitroso-containing compound that acts as a nitric oxide donor in pancreatic islets; induces death of insulin-secreting cells, producing an animal model of diabetes. Potent DNA methylating agent that induces chromosomal breakage. Cytotoxic to neuroendocrine tumor cell lines that express the GLUT2 glucose transporter.


Soluble in water (50 mg/mL - clear to slightly hazy, light yellow solution) and ethanol.

Formule: C₈H₁₅N₃O₇
Poids moléculaire: 265.2 g/mol
Point de fusion: 121 °C (déc., lit.)
Température de stockage: Congélateur
Numéro MDL: MFCD00006607
Numéro CAS: 18883-66-4
EINECS: 242-646-8

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Résultats des tests de spécification

Identity Test Passes
Purity ≥97%
Alpha Anomer ≥75.0%
FTIR Conforms to Standard


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