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Anti-CD34 Mouse Monoclonal Antibody [clone: 581] (PE)

Fournisseur: STEMCELL Technologies
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Total Evaluation: 0
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60013PE 60013PE.1
STMC60013PEEA 570 EUR
STMC60013PE STMC60013PE.1
Anti-CD34 Mouse Monoclonal Antibody [clone: 581] (PE)
Anticorps
Mouse monoclonal IgG1 antibody against human CD34, PE-conjugated.

  • Hematopoietic stem
  • Progenitor cells

The 581 antibody reacts with human CD34, an ~105 - 120 kDa type 1 transmembrane glycoprotein expressed on the surface of most human hematopoietic stem and progenitor cells (HSPCs) as well as on mesenchymal stem cells, embryonic fibroblasts, endothelial cells, neurons, and some tumor cell lines. CD34 is expressed only transiently during hematopoiesis, so the frequency of CD34+ cells is low in bone marrow or cord blood (~1 - 5%) and very low (~0.1 - 0.5%) in peripheral blood. CD34 is a marker used to identify and isolate HSPCs capable of cell engraftment. CD34 is thought to mediate attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells during early hematopoiesis, and to be involved in lymphocyte recruitment through binding to the ligands L- and E-selectin. Distinct epitope groups have been assigned to CD34 based on their sensitivity to enzymatic cleavage, with the 581 antibody recognizing a class III epitope (resistant to neuraminidase and O-glycoprotease). This antibody clone has been verified for purity assessments of cells isolated with EasySep™ Human CD34 Positive Selection Kit (Catalog #18056) and for labeling human mesenchymal cells grown in MesenCult™ Proliferation Kit (Human; Catalog #05411).

Attention: Product restrictions: (i) Customer shall not make products or any portion of them in any way, shape or form, including as a component of another product available for the purpose of further resale or alter or remove the Product label and the Supplier’s mark of origin without express written permission of Supplier and (ii) Customer is familiar with Supplier’s restrictions on the use of the products and shall use the products in compliance with such restrictions and the applicable Supplier Product Information sheet (collectively, the 'Product Restrictions').

Type:
Antigen: CD34
Clonality: Monoclonal
Clone: 581
Conjugation: PE
Epitope:
Host: Mouse
Isotype: IgG1 kappa
Reactivity: Human
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