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Gliotoxin, gladiocladium fimbriatum (de Gladiocladium fimbriatum) ≥97% (par HPLC, TLC)

Marques : ENZO LIFE SCIENCES
Ratings: Ecrire un avis

Total Evaluation: 0
Moyenne des Notes : 0.0 sur 5

Synonyme(s): 2,3,5a,6-Tetrahydro-6-hydroxy-3(hyroxymethyl)-2-methyl-10H-3a,10a-epidithio-pyrazinol[1,2α]indole-1,4-dione

BMLPI1290002 BMLPI1290010
ENZOBMLPI1290002EA 161 EUR
ENZOBMLPI1290002 ENZOBMLPI1290010
Gliotoxin, gladiocladium fimbriatum (de Gladiocladium fimbriatum) ≥97% (par HPLC, TLC)
Gliotoxin

Immunomodulating mycotoxin which acts by blocking membrane thiol groups. Inhibits the chymotrypsin-like activity of the 20S proteasome in a non-competitive manner. Causes apoptotic cell death in macrophages and thymocytes. Induces Ca2+ release from intact rat liver mitochondria. Inhibits the activation of transcription factor NF-κB in response to a variety of stimuli in T and B cells. Displays anti-inflammatory activity in vivo. Antioxidant. Inhibitor of farnesyltransferase and geranylgeranyltransferase I. A negative control analog is available. Displays anti-tumor activity against breast cancer in vivo.


  • Proteasome inhibitor


White to yellow crystalline solid.


Soluble in DMSO or methanol (10mg/ml).

Formule: C₁₃H₁₄N₂O₄S₂
Poids moléculaire: 326.4 g/mol
Température de stockage: Congélateur
Numéro CAS: 67-99-2

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