Gambogic amide ≥98% (par CCM)
Marques : ENZO LIFE SCIENCESTotal Evaluation: 0
Moyenne des Notes : 0.0 sur 5
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Danger
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TrkA ligand
A novel small molecule NGF mimic discovered using a cell-based chemical genetic screen for TrkA agonists. Gambogic amide selectively binds to TrkA, triggers its tyrosine phosphorylation, elicits PI3-kinase/Akt and MAPK activation, provokes neurite outgrowth in PC12 cells and prevents neuronal cell death. EC50 for antiapoptotic activity is 5nM.
Soluble in DMSO (20 mg/ml) or ethanol (20 mg/ml).
Formule:
C₃₈H₄₅NO₇ Point de fusion: 74…76 °C Température de stockage: Température ambiante |
Numéro CAS:
286935-60-2 |
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Résultats des tests de spécification
Purity | ≥98% (TLC) |
Appearance | Yellow-orange solid |
Melting Point | 74 - 76°C |
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