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Icilin ≥97% (par CCM)

Marques : ENZO LIFE SCIENCES
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Synonyme(s): AG 3-5, 3,6-Dihydro-1-(2-hydroxyphenyl)-4-(3-nitrophenyl)-2(1H)-pyrimidinone., 3-(2-Hydroxyphenyl)-6-(3-nitrophenyl)-3,4-dihydropyrimidin-2(1H)-one

BMLCM1260010 BMLCM1260050
ENZOBMLCM1260010EA 110 EUR
ENZOBMLCM1260010 ENZOBMLCM1260050
Icilin ≥97% (par CCM)
Icilin

TRPM8 activator.


Cooling agent. Strongly activates TRPM8 (IC₅₀ = 0.2 µM), cold menthol receptor 1 (CMR1, IC₅₀ = 0.36 µM), a nonselective, cold-activated cation channel and TRPA1 (at 10- to 100-fold higher concentration). Induces currents in TRPM8 expressing HEK 293 cells (EC₅₀ = 0.36 mM) more potently than menthol or low temperatures. Activates TRPM8 with variable latency, followed by extensive desensitisation provided calcium is present. The effects of icilin can be impacted by both pH and cytosolic calcium levels.


Soluble in DMSO (50 mg/ml).

Formule: C₁₆H₁₃N₃O₄
Poids moléculaire: 311.297 g/mol
Numéro MDL: MFCD01689072
Numéro CAS: 36945-98-9
https://digitalassets.avantorsciences.com/adaptivemedia/rendition?id=e1459df02f8118d4ea211fb6caea9176f825aebd&vid=667853c64c6f16c18e9c535f3dc2b27d6a02d583&prid=web&clid=SAPDAM

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Résultats des tests de spécification

Purity ≥97% (TLC)


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