Paclitaxel 98
Marques : ENZO LIFE SCIENCESTotal Evaluation: 0
Moyenne des Notes : 0.0 sur 5
Ultra-pure; stabilizes microtubules
Antitumor agent. Stabilizes microtubules and lowers the critical concentration for tubulin polymerization. Reversibly binds to polymerized tubulin. Inhibits protein isoprenylation and induces apoptosis in PC-3 human prostate cancer cells. The checkpoint of mitotic spindle assembly, aberrant activation of cyclin-dependent kinases (CKDs) and the c-Jun N-terminal kinase/stress activated protein kinase (JNK/SAPK) are involved in Paclitaxel-induced apoptosis.
Isolated from the bark of the Pacific Yew tree (Taxus brevifolia)
Formule:
C₄₇H₅₁NO₁₄ Poids moléculaire: 853.91 g/mol |
Numéro MDL:
MFCD00869953 Numéro CAS: 33069-62-4 |
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