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Dexamethasone ≥99% (par CCM)

Marques : ENZO LIFE SCIENCES
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Total Evaluation: 0
Moyenne des Notes : 0.0 sur 5

Synonyme(s): Dexamethasonum

BMLEI1260001 BMLEI1260005
ENZOBMLEI1260001EA 89.1 EUR
ENZOBMLEI1260001 ENZOBMLEI1260005
Dexamethasone ≥99% (par CCM)
Dexamethasone

Glucocorticoid receptor ligand


Anti-inflammatory glucocorticoid with anti-inflammatory activity. Induces the production of phospholipase A2 inhibitory protein (lipocortin). Inhibits induction of nitric oxide synthase (NOS) (IC50=5nM). Induces apoptosis in eosinophils, but inhibits it in neutrophils. Both effects are blocked by RU-486. Modulates osteogenesis of mesenchymal stem cells. Inhibits constitutive OPG mRNA steady-state levels in a dose- and time-dependent fashion, promoting osteoclast formation. Oral dexamethasone administration induces an increase in insulin resistance in humans. Activates Indoleamine 2,3-dioxygenase (IDO) in plasmacytoid dendritic cells in vivo and thus promotes tryptophan catabolism and thereby suppression of T cells.

Formule: C₂₂H₂₉FO₅
Numéro MDL: MFCD00064136
Numéro CAS: 50-02-2
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