Imprimer

Aristolochic acid ≥98%, solide cristallin

Marques : Cayman Chemical
Ratings: Ecrire un avis

Total Evaluation: 0
Moyenne des Notes : 0.0 sur 5

Danger

21520-100 21520-25 21520-10 21520-50
CAYM21520-100EA 315 EUR
CAYM21520-100 CAYM21520-25 CAYM21520-10 CAYM21520-50
Aristolochic acid ≥98%, solide cristallin
Aristolochic acid

Aristolochic acid is an alkaloid originally isolated from A. radix that inhibits inflammatory phospholipase A₂ (PLA₂) activity (IC₅₀=40 µM in human neutrophils).


It inhibits human synovial fluid PLA₂-induced edema in a dose-dependent manner in vivo which positively correlates with in vitro inhibition of PLA₂. Aristolochic acid inhibits hemolytic activity of PLA₂s TFV PL-X, TFV PL-Ia, and TFV PL-Ib from T. flavoviridis venom (IC₅₀s=4.6, 4.0, and 3.9 µM, respectively) but enhances the edema-inducing activity of TFV PL-Ia and TFV PL-Ib. Aristolochic acid exposure is also associated with progressive interstitial fibrosing nephropathy and upper urinary tract urothelial carcinomas.

Formule: C₁₇H₁₁NO₇
Température de stockage: Congélateur
Numéro MDL: MFCD00238539
Numéro CAS: 313-67-7
UN: 1544
ADR: 6.1,III

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Résultats des tests de spécification

Purity ≥98%
Formulation A Crystalline Solid
λmax 224, 320, 388 nm


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