L-Arginine chlorhydrate 98.5-101.0% (par titration à l'acide perchlorique), EMPROVE® EXPERT JP, USP, BP, Ph. Eur., très pur pouvant être utilisé comme excipient, SAFC®
Marques : MERCK PRODUCTION CHEMICALS
Ratings:
Ecrire un avis
Total Evaluation: 0
Moyenne des Notes : 0.0 sur 5
Synonyme(s):
(S)-(+)-Arginine chlorhydrate, L(+)-Arginine chlorhydrate
1.01544.1000
1.01544.5000
1.01544.9010
1.01544.1000EA
1030
EUR
1.01544.1000
1.01544.5000
1.01544.9010
L-Arginine chlorhydrate 98.5-101.0% (par titration à l'acide perchlorique), EMPROVE® EXPERT JP, USP, BP, Ph. Eur., très pur pouvant être utilisé comme excipient, SAFC®
L-Arginine chlorhydrate
Elemental impurity specifications have been set considering ICH Q3D (Guideline for Elemental Impurities). Class 1-3 elements are not likely to be present above the ICH Q3D option 1 limit, unless specified and indicated (*).
|
Formule:
C₆H₁₅ClN₄O₂ Poids moléculaire: 210.66 g/mol Point de fusion: 218 Densité: 1.42 g/cm³ (20 °C) Température de stockage: Température ambiante |
Numéro MDL:
MFCD00064550 Numéro CAS: 1119-34-2 EINECS: 214-275-1 Indice Merck: 13,00785 |
Résultats des tests de spécification
| Assay (perchloric acid titration, calculated on dried substance) | 98.5 - 101.0 % |
| Identity (IR-spectrum) | passes test |
| Identity (Chloride) | passes test |
| Appearance | white to almost white or colorless, irregular crystals |
| Appearance of solution (50 g/l; water) | clear and not more intense in color than reference solution BY₆ |
| Appearance of solution (100 g/l, water) | clear and colorless |
| pH (100 g/l, CO₂-free water) | 4.7 - 6.2 |
| Spec. rotation (α 20/D, 80 g/l, hydrochloric acid 250 g/l, calc. on dried substance) | +21.0 to +23.5 |
| Spec. rotation (α 20/D, 80 g/l, hydrochloric acid 6 mol/l, calc. on dried substance) | +21.4 to +23.6 |
| Spec. rotation (α 20/D, 80 g/l, hydrochloric acid 6 mol/l,previously dried substance) | +21,5 to +23,5 |
| Chloride (Cl) (argentometric) | 16.5 - 17.1 % |
| Sulfate (SO₄) | ≤ 200 ppm |
| Heavy metals (as Pb) | ≤ 10 ppm |
| As (Arsenic) | ≤ 2 ppm |
| Fe (Iron) | ≤ 10 ppm |
| NH₄ (Ammonium) | ≤ 200 ppm |
| Related Compounds, total (TLC) | ≤ 0.5 % |
| Related substances (TLC) | passes test |
| Ninhydrin-positive substances (LC) (any ninhydrin-positive impurity) | ≤ 0.2 % |
| Ninhydrin-positive substances (LC) (ammonium (570 nm)) | ≤ 0.02 % |
| Ninhydrin-positive substances (LC) (total impurities) | ≤ 0.5 % |
| Residual solvents (ICH Q3C) | excluded by manufacturing process |
| Sulfated ash (600 °C) | ≤ 0.1 % |
| Loss on drying (105 °C, 2 h) | ≤ 0.2 % |
| Bacterial endotoxins | ≤ 3.0 I.U./g |
Learn more
About VWR
Avantor is a vertically integrated, global supplier of discovery-to-delivery solutions for...