TRAIL-R1 is a receptor for the cytotoxic ligand TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappaB.
Definition for 1 test: 1ul of labeled antibody in 200ul of Flow Cytometry buffer (see online protocol).
Type: Primary
Antigen: TNFRSF10A
Clonality: Monoclonal
Clone: HS101
Conjugation: ATTO 647N
Epitope:
Host: Mouse
Isotype: IgG1
Reactivity: Human