The human Mel-CAM gene maps to chromosome 11q23 and encodes a trans-membrane glycoprotein, also designated MCAM, MUC 18 or CD146, that belongs to the immunoglobulin superfamily and functions as a Ca2 -independent cell adhesion molecule. Mel-CAM expression is restricted to advanced primary and metastatic melanomas and to cell lines of the neuroectodermal lineage, but not normal melanocytes. Mel-CAM is found on 80% of advanced primary human melanomas and correlates well with development of metastatic disease.
Type: Primary
Antigen: MCAM
Clonality: Monoclonal
Clone: Clone OJ79c
Conjugation: CF640R
Epitope:
Host: Mouse
Isotype: IgG1 kappa
Reactivity: Human