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Anti-TP53 Mouse Monoclonal Antibody (CF640R) [clone: DO-7]

Fournisseur: Biotium
Ratings: Ecrire un avis

Total Evaluation: 0
Moyenne des Notes : 0.0 sur 5

BNC400513-500 BNC400513-100
BNC400513-500EA 560 EUR
BNC400513-500 BNC400513-100
Anti-TP53 Mouse Monoclonal Antibody (CF640R) [clone: DO-7]
Anticorps
Recognizes a 53 kDa protein, which is identified as p53 suppressor gene product. It reacts with the mutant as well as the wild form of p53. Its epitope maps within the N-terminus (aa 37-45) of p53. Monoclonal antibody PAb1801 does not block the binding of DO-7 MAb to p53 in an ELISA test. p53 is a tumor suppressor gene expressed in a wide variety of tissue types and is involved in regulating cell growth, replication, and apoptosis. It binds to MDM2, SV40 T antigen and human papilloma virus E6 protein. Positive nuclear staining with p53 antibody has been reported to be a negative prognostic factor in breast carcinoma, lung carcinoma, colorectal, and urothelial carcinoma. Anti-p53 positivity has also been used to differentiate uterine serous carcinoma from endometrioid carcinoma as well as to detect intratubular germ cell neoplasia. Mutations involving p53 are found in a wide variety of malignant tumors, including breast, ovarian, bladder, colon, lung, and melanoma.

Type: Primary
Antigen: TP53
Clonality: Monoclonal
Clone: DO-7
Conjugation: CF640R
Epitope:
Host: Mouse
Isotype: IgG2b kappa
Reactivity: Cow, Human, Monkey
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