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Anti-TP53 Rabbit Monoclonal Antibody (CF405S) [clone: PAb122]

Fournisseur: Biotium
Ratings: Ecrire un avis

Total Evaluation: 0
Moyenne des Notes : 0.0 sur 5

BNC040338-500 BNC040338-100
BNC040338-500EA 560 EUR
BNC040338-500 BNC040338-100
Anti-TP53 Rabbit Monoclonal Antibody (CF405S) [clone: PAb122]
Anticorps
PAb122 binds to the C-terminus (aa370-378) of both wild type and mutated p53. When microinjected into nuclei, PAb122 blocked re-entry into the S-phase of the cell cycle. Mutation and/or allelic loss of p53 is one of the causes of a variety of mesenchymal and epithelial tumors. If it occurs in the germ line, such tumors run in families. p53 Binds to a DNA consensus sequence, the p53 response element, and it regulates normal cell growth cycle events by activating transcription of genes, involved either in progression through the cycle, or causing arrest in G1 when the genome is damaged. InEn savoir plus
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SPÉCIFICATIONS

Symbole de l'antigène TP53
Environmentally Preferable
Nom de l'antigène p53
Synonymes antigène Transformation Related Protein 53 (TRP53)|Tumor Protein p53|BCC7|Cellular Tumor Antigen p53|Tumor Suppressor p53|TP53|LFS1|Antigen NY-CO-13
Type d'anticorps Primaire
Clonalité Monoclonal
Conjugaison CF® 405S
Clone Clone PAb122
Réactivité Hamster,Monkey,Human,Dog,Rat,Mouse
Hôte Rabbit
ID de gène 654481
Isotype IgG2b kappa
ImmunoChimie Yes
ImmunoFluorescence Yes
Concentration 0,1 mg/ml
Storage buffer PBS/0,1% BSA/0,05% azide

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