Imprimer

SPB (Succinimidyl-[4-(psoralen-8-yloxy)]butyrate), Pierce™

Marques : Thermo Fisher Scientific
Ratings: Ecrire un avis

Total Evaluation: 0
Moyenne des Notes : sur 5

23013
PIER23013EA 270 EUR
PIER23013
SPB (Succinimidyl-[4-(psoralen-8-yloxy)]butyrate), Pierce™
SPB (Succinimidyl-[4-(psoralen-8-yloxy)]butyrate)

Thermo Scientific Pierce SPB is an NHS-ester and psoralen crosslinker that effectively conjugates primary amines to DNA via light-activated intercalation next to pyrimidine bases.


  • Reactive groups: NHS ester and psoralen
  • Reactive toward: amino groups and thymine
  • DNA intercalating agent and nucleic acid probe
  • Reagent for photo-immobilization to microplates


Sulfosuccinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (Sulfo-SMCC) is a non-cleavable and membrane impermeable crosslinker. It contains an amine-reactive N-hydroxysuccinimide (NHS ester) and a sulfhydryl-reactive maleimide group. NHS esters react with primary amines at pH 7-9 to form stable amide bonds. Maleimides react with sulfhydryl groups at pH 6.5-7.5 to form stable thioether bonds. The maleimide groups of Sulfo-SMCC and SMCC are unusually stable up to pH 7.5 because of the cyclohexane bridge in the spacer arm. Because it contains the hydrophilic sulfonyl moiety, Sulfo-SMCC is soluble up to ∼10 mM in water and many commonly used buffers, thus avoiding the use of organic solvents which may perturb protein structure.


Attention: For Research Use Only. Not for use in diagnostic procedures.

Formule: C₁₉H₁₅NO₈
Poids moléculaire: 385.32 g/mol
Point de fusion: 177…178°C
Température de stockage: Réfrigérateur
Numéro MDL: MFCD29041827
Numéro CAS: 858128-57-1

Commander maintenant

Résultats des tests de spécification

Product Line Pierce™
Labeling Method Chemical Labeling
Crosslinker Type Heterobifunctional
Reactive Moiety Psoralen, NHS Ester
Spacer Short
Form Solid
Quantity 50 mg
Type Crosslinker
Solubility DMF, DMSO


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