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Oxamflatin 95 HPLC_ASSAY_METHOD

Marques : ENZO LIFE SCIENCES
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Moyenne des Notes : sur 5

ALX270379M005
ENZOALX270379M005EA 527 EUR
ENZOALX270379M005
Oxamflatin 95 HPLC_ASSAY_METHOD
Oxamflatin

HDAC inhibitor


Potent inhibitor of mammalian HDACs (histone deacetylases) (IC50=15.7nM). Acts as a ligand for the enzyme active site metal ion. Upregulates plasminogen activator inhibitor type 2 (PAI-2) expression with concomitant inhibition of urokinase (u-PA) gene and protein expression in HT-1080 and U-937 cells. Elevates the expression of extracellular matrix proteins fibronectin and gelsolin. Induces apoptosis in P-glyoprotein (Pgp) positive and Pgp negative multidrug resistant cells.

Numéro CAS: 151720-43-3

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