Votre recherche pour: STAT3+Inhibitor+V,+Stattic

Référence Produit: (PRSI27-057)

Fournisseur: ProSci Inc.

Description: IL15 is a cytokine that regulates T and natural killer cell activation and proliferation. This cytokine and interleukine 2 share many biological activities. They are found to bind common hematopoietin receptor subunits, and may compete for the same receptor, and thus negatively regulate each other's activity. The number of CD8+ memory cells is shown to be controlled by a balance between this cytokine and IL2. This cytokine induces the activation of JAK kinases, as well as the phosphorylation and activation of transcription activators STAT3, STAT5, and STAT6. Studies of the mouse counterpart suggested that this cytokine may increase the expression of apoptosis inhibitor BCL2L1/BCL-x (L), possibly through the transcription activation activity of STAT6, and thus prevent apoptosis.The protein encoded by this gene is a cytokine that regulates T and natural killer cell activation and proliferation. This cytokine and interleukine 2 share many biological activities. They are found to bind common hematopoietin receptor subunits, and may compete for the same receptor, and thus negatively regulate each other's activity. The number of CD8+ memory cells is shown to be controlled by a balance between this cytokine and IL2. This cytokine induces the activation of JAK kinases, as well as the phosphorylation and activation of transcription activators STAT3, STAT5, and STAT6. Studies of the mouse counterpart suggested that this cytokine may increase the expression of apoptosis inhibitor BCL2L1/BCL-x (L), possibly through the transcription activation activity of STAT6, and thus prevent apoptosis. Two alternatively spliced transcript variants of this gene encoding the same protein have been reported.

UOM: 1 * 50 µG

*Promo

Référence Produit: (PRSI7231)

Fournisseur: ProSci Inc.

Description: IL-15 Antibody: Interleukin 15 (IL-15) is a cytokine that regulates T and natural killer cell activation and proliferation. This cytokine and IL-2 share many biological activities as both have been found to bind common hematopoietin receptor subunits, and may compete for the same receptor, and thus negatively regulate each other's activity. The number of CD8+ memory cells is shown to be controlled by a balance between IL-15 and IL-2. This cytokine induces the activation of JAK kinases, as well as the phosphorylation and activation of transcription activators STAT3, STAT5, and STAT6. In mouse, studies suggest that IL-15 may increase the expression of apoptosis inhibitor Bcl-xL, possibly through the transcription activation activity of STAT6, and thus prevent apoptosis.

UOM: 1 * 100 µG

*Promo

Référence Produit: (PRSI91-880)

Fournisseur: ProSci Inc.

Description: Interleukin 10(IL10), also known as cytokine synthesis inhibitory factor (CSIF),is a secreted protein and belongs to the IL-10 family. IL-10 is secreted by many activated hematopoietic cell types as well as hepatic stellate cells, keratinocytes, and placental cytotrophoblasts . IL-10 is an anti-inflammatory TH2 cytokine that has a critical role in limiting the immune response to pathogens to prevent host damage. As IL-10 in produced in several T helper populations, it is proposed that it provides a feedback loop to limit the effector functions of macrophages and DCs on T cells. Once expressed, IL-10 signals through the IL-10 receptor (IL-10R) to activate STAT3. As IL-10 is a strong inhibitor of inflammation, it has become a viable biomarker for various diseases and conditions as well as a therapeutic molecule for certain conditions. In addition to elevated levels in parasitic infection, high expression levels of IL-10 are also found in retroviral infections inducing immunodeficiency. The immunosuppressive properties of IL-10 suggest a possible clinical use of IL-10 in suppressing rejections of grafts after organ transplantations

UOM: 1 * 50 µG

*Promo

Référence Produit: (PRSI91-129)

Fournisseur: ProSci Inc.

Description: Interleukin-20 (IL-20) is a member of the IL-10 family of regulatory cytokines that includes IL-10, IL-19, IL-20, IL-22, IL-24 and IL-26. Members of this family share partial homology in their amino acid sequences but they are dissimilar in their biological functions. IL-20 exhibits approximately 28% amino acid identity with IL-10 and 76% amino acid identity with mouse IL-20. There are two heterodimeric receptor complexes for IL-20. The first is composed of IL-20 R alpha and IL-20 R beta . The second is composed of IL-22 R and IL-20 R beta . Whereas the IL-22 R/IL-20 R beta complex is shared with IL-24, the IL-20 R alpha/IL-20 R beta complex is shared with both IL-19 and IL-24. IL-20 has been shown to initiate transduction cascades involving STAT3 and stimulates the induction of pro-inflammatory genes including TNF- alpha and MCP-1. Initial functional studies using transgenic mice suggest that IL-20 has the ability to regulate skin development. The over-expression of both human and mouse forms of IL-20 results in keratinocyte hyper-proliferation, abnormal epidermal differentiation, and neonatal lethality. In humans, IL-20 and its receptors are up-regulated in psoriatic skin, and polymorphisms in the IL-20 gene have been associated with plaque-type psoriasis. IL-20 may also have a role in hematopoiesis. It enhances the proliferation of multi-potential progenitors in vitro and increases their numbers and cell cycling status in IL-20 transgenic mice. IL-20 is also shown to suppress COX-2 and PGE2 and acts as an inhibitor of angiogenesis in model systems.

UOM: 1 * 50 µG

*Promo

Référence Produit: (ABGEAP20324B)

Fournisseur: Abgent

Description: Anti-STAT3 Rabbit Polyclonal Antibody

UOM: 1 * 400 µl

*Promo

Référence Produit: (USBIS7971-02K)

Fournisseur: US Biological

Description: Anti-STAT3 Rabbit Polyclonal Antibody

UOM: 1 * 40 µG

*Promo

Référence Produit: (USBIS7971-20E)

Fournisseur: US Biological

Description: Anti-STAT3 Rabbit Polyclonal Antibody

UOM: 1 * 50 µG

*Promo

Référence Produit: (USBIS7971-01U)

Fournisseur: US Biological

Description: Anti-STAT3 Rabbit Polyclonal Antibody

UOM: 1 * 100 µG

*Promo

Référence Produit: (USBIS7971-01B1)

Fournisseur: US Biological

Description: Anti-STAT3 Rabbit Polyclonal Antibody

UOM: 1 * 100 µl

*Promo

Référence Produit: (BWRLAP0366)

Fournisseur: Bioworld Technology

Description: Synthetic peptide, corresponding to amino acids 700-750 of Human Stat3.

UOM: 1 * 100 µG

*Promo

Référence Produit: (USBIS7971-20C-BIOT)

Fournisseur: US Biological

Description: Anti-STAT3 Rabbit Polyclonal Antibody (Biotin)

UOM: 1 * 200 µl

*Promo

Référence Produit: (USBI042383-BIOTIN)

Fournisseur: US Biological

Description: Anti-STAT3 Rabbit Polyclonal Antibody (Biotin)

UOM: 1 * 200 µl

*Promo

Référence Produit: (BWRLBS4181)

Fournisseur: Bioworld Technology

Description: Synthetic phosphopeptide derived from human Stat3 around the phosphorylation site of Tyrosine 705.

UOM: 1 * 100 µG

*Promo

Référence Produit: (BWRLBS4180)

Fournisseur: Bioworld Technology

Description: Synthetic phosphopeptide derived from human Stat3 around the phosphorylation site of Serine 727.

UOM: 1 * 100 µG

*Promo

Référence Produit: (ABCAAB109085-100)

Fournisseur: Abcam

Description: Anti-STAT3 Rabbit Monoclonal Antibody [clone: EPR361]

UOM: 1 * 100 µl

*Promo

Référence Produit: (BWRLAP0365)

Fournisseur: Bioworld Technology

Description: Synthetic peptide, corresponding to amino acids 680-720 of Human Stat3.

UOM: 1 * 100 µG

*Promo